Haixiang Sun

No ORCID on file · 21 papers in corpus · active 2011-2024

Study types

  • article 13
  • other 6
  • preprint 2

Condition tags

  • endometriosis 12
  • infertility 9
  • adenomyosis 8
other 2024
Biochemical and biophysical research communications ·doi:10.1016/j.bbrc.2024.151004

A successful embryo implantation relies heavily on the receptivity of the endometrial epithelium, a process regulated by various molecular mechanisms. Evaluating endometrial receptivity in infertility patients undergoing assisted reproducti…

article 2022
Biology of reproduction ·doi:10.1093/biolre/ioac041

Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in EMs. Whether CAPN7 a…

preprint 2022
·doi:10.21203/rs.3.rs-1800392/v1
other 2022
Cell death discovery ·doi:10.1038/s41420-022-01196-x

Decidualization is a prerequisite for successful embryo implantation, in which elongated fibroblast-like endometrial stromal cells differentiate into more rounded decidual cells. Accumulating evidence has stressed the important role of the …

article 2022
Reproductive and developmental medicine ·doi:10.1097/rd9.0000000000000015

The impact of coronavirus disease 2019 (COVID-19) on endometriosis (EM) is currently unclear. Here, we aimed to describe the potential influence of COVID-19 on the pathogenesis, clinical symptoms, and treatment of EM. The cytokine storm cau…

article 2022
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-021-00881-3

BACKGROUND: Adenomyosis is a chronic gynecological disease characterized by invasion of the uterine endometrium into the muscle layer. In assisted reproductive technology (ART), gonadotropin-releasing hormone agonist (GnRHa) is often used t…

article 2021
Biology of reproduction ·doi:10.1093/biolre/ioab182

The establishment of endometrial receptivity is a prerequisite for successful pregnancy. Women with adenomyosis possess a lower chance of clinical pregnancy after assisted reproductive technology, which is partially due to impaired endometr…

preprint 2021
·doi:10.21203/rs.3.rs-985926/v1

Abstract Background Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in …

other 2020
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.07.027

RESEARCH QUESTION: Does adenomyosis affect IVF independent of decreased ovarian reserve, and what are the characteristics and IVF outcome of the ultra-long gonadotrophin-releasing hormone (GnRH) agonist protocol in adenomyosis? DESIGN: Obs…

article 2019
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13166

PROBLEM: During endometriosis, there is an increase in the number of dysfunctional macrophages; however, the mechanisms underlying macrophage recruitment are not well understood. The aim of the present study was to determine the role of nat…

other 2019
Biology of reproduction ·doi:10.1093/biolre/ioz026

Impaired decidualization has been considered a major cause of infertility in adenomyosis. However, the mechanism remains poorly understood. Recent studies suggest that microRNAs (miRNA) play a crucial role in embryo implantation. The aim of…

article 2019
Systems biology in reproductive medicine ·doi:10.1080/19396368.2018.1563844

Long non-coding RNAs (lncRNAs), a class of non-coding RNA, have been shown to be essential in many diseases, such as infertility. Here, we found three candidate lncRNAs, ENST00000414116, ENST00000433673, and ENST00000448179, that are highly…

other 2018
Cell death & disease ·doi:10.1038/s41419-018-0317-3

Endometriosis (ENDO) is a common gynecological disease that causes infertility in many women. Previous studies noted that the dysregulation of Homeo box A10 (HOXA10) in the endometrium of women with ENDO was involved in the failure of embry…

article 2018
BioMed research international ·doi:10.1155/2018/2549789

OBJECTIVE: The aim of this study was to investigate the potential role of IL-10 in regulating the receptivity marker HOXA10 in the endometrium of women with adenomyosis. METHODS: The expression levels of IL-10, HOXA-10, STAT3, and p-STAT3 i…

article 2017
·doi:10.1016/j.fertnstert.2017.07.629
article 2017
Molecular medicine reports ·doi:10.3892/mmr.2017.6242

It was previously demonstrated that anomalous expression of indoleamine 2,3-dioxygenase-1 (IDO1) in endometrial stromal cells (ESCs) stimulated an inflammatory response that subsequently initiated the activation of immunosuppressive macroph…

other 2016
Molecular human reproduction ·doi:10.1093/molehr/gaw042

STUDY QUESTION: How do NR4A receptors drive decidualization of human endometrial stromal cells (hESCs)? SUMMARY ANSWER: NR4A receptors modulate endometrial decidualization by transcriptional activation of FOXO1A, and in adenomyosis patient…

article 2016
Molecular medicine reports ·doi:10.3892/mmr.2016.5997

The chemokine stromal cell-derived factor-1 (C-X-C motif chemokine ligand 12; CXCL12) is important in the recruitment of leukocytes to the peritoneal cavity and the regulation of endometriotic tissue growth in endometriosis patients. Howeve…

article 2015
·doi:10.1186/s12958-015-0019-y

BACKGROUND: The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we ex…

article 2013
Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-11-64

BACKGROUND: Matrix metalloproteinase 2 (MMP-2) has been reported to be an important regulator of cell migration and invasion through degradation of the extracellular matrix (ECM) in many diseases, such as cancer and endometriosis. Here, we …

article 2011
·doi:10.1016/j.biomaterials.2011.07.050