Daniel Fink

Although endometriosis is a common gynaecological clinical picture in women of reproductive age, diagnosis and therapy often begin late after the onset of symptoms. The explanation probably lies on the one hand in the manifold manifestation…

PurposeProposal of a systematic approach to assess Deep infiltrating endometriosis (DIE) through pelvic Magnetic resonance imaging (MRI) using the Enzian classification and examination of inter-rater agreement.MethodsThree radiologists revi…

BACKGROUND: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor i…

Research questionWhat are the specific characteristics of sexual activity in women with endometriosis compared with women without endometriosis?DesignMulticentre case control study. Participants were recruited from university hospitals, dis…

PurposeComparison of preoperative magnetic resonance imaging (MRI) with intraoperative findings in patients with deep infiltrating endometriosis (DIE) by means of the ENZIAN score.MethodsThis retrospective two-center study includes 63 patie…

STUDY QUESTION: Is fatigue a frequent symptom of endometriosis? SUMMARY ANSWER: Fatigue is an underestimated symptom of endometriosis as it affects the majority of women with endometriosis, but it is not widely discussed in literature. WHAT…

OBJECTIVE: To investigate the prevalence of miscarriage in women with endometriosis (WwE) compared with disease-free control women (CW). DESIGN: Cross-sectional analysis nested in a retrospective observational study (n = 940). SETTING: Ho…

Chlamydia trachomatis is the most common bacterial cause of sexually transmitted disease and can cause pelvic inflammatory disease (PID), leading to severe outcomes such as ectopic pregnancy, infertility, or pelvic pain. We report a case of…

Endometriosis is a common gynecologic benign disease, affecting 6–10% of women of reproductive age. The disease is often associated with dysmenorrhea, dyspareunia, chronic pelvic pain and infertility. The exact mechanism of the pathogenesis…

Endometriose definiert sich durch das Vorhandensein von endometriumartiger Schleimhaut ausserhalb des Cavum uteri. Es handelt sich dabei um eine häufige Krankheit, man geht davon aus, dass ca. 6–10% der Frauen im reproduktiven Alter an Endo…

Endometriosis is a common gynecological disease affecting 6%-10% of women of reproductive age and is characterized by the presence of endometrial-like tissue in localizations outside of the uterine cavity as, e.g., endometriotic ovarian cys…

ObjectiveTo investigate whether histone deacetylase inhibitors reduce the expression of the G-protein-coupled estrogen receptor (GPER) and whether the functional inhibition of GPER by the antagonist G-15 decreases the proliferation of endom…

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis s…

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis s…

Abstract: Endometriosis is a common gynecological disease affecting 6%–10 % of women of reproductive age and is characterized by the presence of endometrial-like tissue in localizations outside of the uterine cavity as, e.g., endometriotic …

BACKGROUND: The G protein-coupled estrogen receptor (GPER) is thought to be involved in non-genomic estrogen responses as well as processes such as cell proliferation and migration. In this study, we analyzed GPER expression patterns from e…

Mutations of the tumor-suppressor gene ARID1A result in the loss of protein expression of the BRG-associated factor 250a (BAF250a), a large subunit of transcription-regulating Human SWI/SNF complexes, which have an important role in the con…

Endometriose, definiert als das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb des Cavum uteri, ist eine häufige Ursache für chronische Unterbauchschmerzen, Dysmenorrhö und Sterilität. Insbesondere die medikamentös…

Endometriose, definiert als das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb des Cavum uteri, ist eine häufige Ursache für chronische Unterbauchschmerzen, Dys menorrhö und Sterilität. Insbesondere die medikamentö…

Endometriose ist eine facettenreiche Erkrankung an der weltweit ungefähr 176 Mio. Frauen leiden. Die Erkrankung definiert sich durch das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb Cavum uteri, wobei die Ätiopat…

BACKGROUND/AIMS: Endometriosis is a benign but chronic disorder associated with pelvic pain and infertility. Enhanced proliferation and reduced apoptosis susceptibility are characteristics of endometriosis. Cordycepin is a poly(A) polymeras…

ObjectiveTo investigate whether the histone deacetylase (HDAC) inhibitor romidepsin down-regulates VEGF (vascular endothelial growth factor) gene expression and abrogates VEGF protein secretion in human epithelial endometriotic cells.Design…