Wei Zhang

BACKGROUND: Endometriosis is a benign gynecological disorder which shares certain characteristics with malignant tumor like migration, invasion and proliferation. Glioma-associated oncogene homolog 1 (GLI1) has been implicated in some cance…

Objective To investigate the safety and feasibility of robotic single-site laparoscopy in gynecological surgery. Methods Clinical data of seven patients undergoing robotic single-site laparoscopic gynecological surgery in the departm…

Abstract Background: To preserve fertility or integrity of organs was on the rise for the most women with adenomyosis. Adenomyomectomy is now a widely applied conservative surgery, however relapse is a serious problem after operation. Posto…

Abstract Background: To preserve fertility or integrity of organs was on the rise for the most women with adenomyosis. Adenomyomectomy is now a widely applied conservative surgery, however relapse is a serious problem after operation. Posto…

Abstract Background: To preserve fertility or integrity of organs was on the rise for the most women with adenomyosis. Adenomyomectomy is now a widely applied conservative surgery, however relapse is a serious problem after operation. Posto…

Disseminated peritoneal leiomyomatosis (DPL), also known as leiomyomatosis peritonealis disseminata, is a rare condition characterized by multiple benign smooth muscle tumors proliferating along the peritoneal surfaces. In previous case rep…

The present study aimed to identify the core genes and pathways involved in depression in patients with ovarian cancer (OC) who suffer from high or low-grade depression. The dataset GSE9116 from Gene Expression Omnibus database was analyzed…

The focus of the current study was a G protein‑coupled estrogen receptor (GPER)/microRNA (miR)‑148a/human leukocyte antigen‑G (HLA‑G) signaling pathway in ovarian endometriosis. Reverse transcription‑quantitative polymerase chain reaction w…

Objective To analyze the feasibility, safety and perioperative outcome of laparoscopic single-site surgery in deeply infiltrating endometriosis. Methods Between May 2017 and Aug. 2018, 6 patients were diagnosed as deeply infiltrating…

Objective: To observe the influence of promoting blood circulation to remove blood stasis \ncombined with laparoscopy on serum MCP-1, RANTES, oxidative stress and hormones \nin infertile patients with endometriosis. Methods: A total of 60 i…

OBJECTIVE: To investigate the role and potential molecular mechanism of Galectin-3 (Gal-3) in the etiology of endometriosis-associated infertility. METHODS: We detected Gal-3 expression in eutopic endometrium from women with endometriosis-a…

This study investigated the risk factors and early predictors for heterotopic pregnancy (HP) after in vitro fertilization and embryo transfer (IVF-ET). From January 2008 to January 2013, 41 cases of HP and 72 cases of intrauterine twin preg…

Hepatic endometriosis is one of the rarest disorders characterized by the presence of ectopic endometrium in the liver. To our knowledge, only 21 cases of hepatic endometrioma have been described in the medical literature. We report a case …

Renal endometriosis is a rare disease for which the mechanisms of pathogenesis are still unclear. As such, early diagnosis and an appropriate treatment are often delayed because of the tendency to be misdiagnosed as a renal tumor. In Octobe…

OBJECTIVE: To study the efficacy and safety of Gonadotropin-releasing hormone agonists (GnRH-a) combined with laparoscope conservative surgery in treatment of moderate or severe endometriosis. METHODS: From Jan. 2007 to Jan. 2010, 68 patien…

OBJECTIVE: To evaluate the lowest effective dose of combined estrogen and progestogen (E(2)+P) add-back therapy during post-operative gonadotropin-releasing hormone agonist (GnRHa) treatment for endometriosis in Chinese women. STUDY DESIGN:…

This paper demonstrates an in vitro model to simulate the microenvironment of endometriosis. We used microfluidic channels with cover slips to pattern and release endometrial stromal cells (ESCs) and human peritoneal mesothelial cells (HPMC…

Objective: To establish endometriosis(EMS) infertility in mice models,observe and compare the difference of expression of chemokine EOTAXIN and its receptor CCR3 between endometriosize pregnant and infertile mice,analyze the effect of EOTAX…

A lack of sensitive and specific tumor markers for early diagnosis and treatment is a major cause for the high mortality rate of ovarian cancer. The purpose of this study was to identify potential proteomics-based biomarkers useful for the …

The present study aimed to assess the impact of post-surgical hormone replacement therapy (HRT) on life quality and prognosis in women with ovarian malignancy. HRT (Premarin, Nilestriol and medroxyprogesterone) was administered following su…

Objective To establish an allograft endmetriosis model.Methods 24 female Wistar rats were used to induce endometriosis through allogeneic uterus transplants.30 female Wistar rats received autologous uterus transplant were used as control.Re…

Objective To explore the effect of sclerosis due to absolute alcohol guided by ultrasound combined with danazol in treatment of ovarian chocolate cyst.Methods 53 patients with ovarian chocolate cyst received the therapy with absolute alcoho…

OBJECTIVE: To assess the sensitivity and positive predictive value (PPV) of intraoperative frozen section diagnosis of the borderline tumor of ovary (BTO). METHODS: A retrospective analysis and comparison were done respectively between the…

Endometriosis(EMs)is a common and frequent gynecopathy.Its pathogenesis is unclear till now.No effective biochemical markers that can be used to diagnose endometriosis are available in clinical work.Many researches showed that the expressio…