Tomio Iwabe

No ORCID on file · 50 papers in corpus · active 1997-2014

Study types

  • article 40
  • review 4
  • book-chapter 3
  • editorial 1
  • letter 1

Condition tags

  • endometriosis 34
  • endometrioma 6
  • infertility 4
  • dysmenorrhea 1
  • adenomyosis 1
book-chapter 2014
Inflammation and Cytokines in Endometriosis
·doi:10.1007/978-4-431-54421-0_7
article 2014
The Cellular Inhibitor of Apoptosis Protein‐2 is a Possible Target of Novel Treatment for Endometriosis
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12193

PROBLEM: How is the tumor necrosis factor (TNF) α-induced inhibitor of apoptosis (IAP) protein expression in endometriotic stromal cells (ESCs) involved in cell viability and signaling pathways? METHOD OF STUDY: Endometriotic stromal cells …

article 2013
0021-972X/04/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 89(2):823–832 Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/jc.2003-030874 Hepatocyte Growth Factor/Met System Promotes

ENDOMETRIOSIS, A COMMON disease among women, is a histologically defined, nonmalignant disease in which endometrium-like tissue is found outside the uterus. Endometriosis may exhibit features similar to malignancy, including aggressive grow…

article 2013
IAP inhibitor represses cell proliferaetion in human endometriotic stromal cells and the development of endometriosis in a murine model
·doi:10.1016/j.fertnstert.2013.07.766
article 2013
Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.06.028

ObjectiveTo evaluate the effects of parthenolide on human endometriotic cells and murine endometriotic lesions.DesignExperimental study.SettingUniversity hospital and laboratory of animal science.Patient(s) and animal(s)Twenty women with ov…

article 2012
Gonadotropin-Releasing Hormone Analogues Reduce the Proliferation of Endometrial Stromal Cells but Not Endometriotic Cells
Gynecologic and obstetric investigation ·doi:10.1159/000343748

AIMS: We investigated the potential of gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists to inhibit cell proliferation in endometriotic and endometrial stromal cells. METHODS: Twenty patients with ovarian endometriomas and…

article 2012
Inhibitor of apoptosis protein (IAP)-2 is a novel therapeutic target for endometriosis
·doi:10.1016/j.fertnstert.2012.07.340
article 2012
The NFκB inhibitor parthenolide reduces cell proliferation and PGE2 synthesis in human endometriotic stromal cells and inhibits development of endometriosis in murine model
·doi:10.1016/j.fertnstert.2012.07.339
review 2012
The role of NF-kappaB in endometriosis
Frontiers in bioscience (Scholar edition) ·doi:10.2741/s327

The nuclear factor kappaB (NF-kappaB) is a ubiquitously expressed transcription factor playing vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. This review highlights the im…

book-chapter 2011
Aberrant Expression of IAP Family in Endometriotic Cells May Cause Resistance to Apoptosis
·doi:10.1210/endo-meetings.2011.part3.p25.p3-172
book-chapter 2011
A Hypomethylated CpG Island in the Aromatase Gene May Cause Up-Regulation in Endometriotic Cells
·doi:10.1210/endo-meetings.2011.part3.p25.p3-181
article 2011
TNFα is a potent mediator of regulating IAP expression in endometriotic cells
·doi:10.1016/j.fertnstert.2011.07.534
article 2010
Aberrant expression of IAP family in endometriotic cells may cause resistance to apoptosis
·doi:10.1016/j.fertnstert.2010.07.779
article 2010
Advanced Techniques of Adhesiolysis for Severe Endometriosis
·doi:10.1016/j.jmig.2010.08.020
review 2010
Apoptosis and endometriosis
Frontiers in bioscience (Elite edition) ·doi:10.2741/e277

Apoptosis is a distinctive form of programmed cell death resulting in the efficient elimination of cells without eliciting an inflammatory response. Endometriosis is characterized by the presence of endometrial cells with capacity to avoid …

article 2010
Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.06.024

ObjectiveTo search for the demethylated cytosine-phosphate-guanine (CpG) islands within the aromatase gene in stromal cells derived from endometriotic chocolate cysts.DesignProspective study.SettingDepartment of Obstetrics and Gynecology an…

article 2010
Table of Contents
·doi:10.1016/s0015-0282(10)02912-2
article 2009
Apigenin inhibits TNFα-induced cell proliferation in endometriotic stromal cells
·doi:10.1016/j.fertnstert.2009.07.042
article 2009
TAK1 activation for cytokine synthesis and proliferation of endometriotic cells
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2009.04.012

Endometriosis causes pelvic pain and infertility in women of reproductive age. We explored TNFalpha-induced specific signaling pathways and gene expressions in endometriotic stromal cells (ESCs). Based on the data of the pathway specific cD…

article 2008
Exploring mechanisms for regulating growth and survival of ectopic endometriotic cells using comprehensive DNA microarray analysis
·doi:10.1016/j.fertnstert.2008.07.236
article 2008
Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2
·doi:10.1016/j.fertnstert.2008.07.235
article 2008
Serum interleukin-8 levels are elevated in patients with ovarian endometrioma
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.07.1355

ObjectiveTo determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool in diagnosing this disease.DesignA controlled clinical study and an in …

article 2007
Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.02.060

Ovarian surface epithelial cells (OSEs) are considered to be the common source of endometrioma and epithelial ovarian cancer. The present study reveals that keratinocyte growth factor receptor (KGFR) messenger RNA was expressed in OSEs of e…

article 2007
Apoptosis and endometriosis
Frontiers in bioscience : a journal and virtual library ·doi:10.2741/2302

Apoptosis plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggest that apoptosis helps to maintain cellular homeostasis during the men…

article 2007
Peroxisome proliferator-activated receptor-γ ligand reduced tumor necrosis factor-α-induced interleukin-8 production and growth in endometriotic stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.03.061

ObjectiveTo evaluate the influence of peroxisome proliferator-activated receptor-gamma (PPAR gamma) ligand (pioglitazone) on tumor necrosis factor-alpha (TNF-alpha)-induced interleukin-8 (IL-8) expression in endometriotic stromal cells (ESC…