Yang Y

BACKGROUND: Endometriosis is a chronic inflammatory disease characterized by immune microenvironment dysregulation, with the IL-33/ST2L signaling axis playing a crucial role in macrophage polarization and disease progression. Despite growin…

The causal role of established risk factors for premenstrual disorders (PMDs) remains unclear. We used Mendelian randomization (MR) to assess causality for eight known-risk factors identified through a literature review. Summary statistics …

Infertility constitutes a major global health concern, affecting approximately 17.5% of couples of reproductive age. Although advances in assisted reproductive technologies (ART) have expanded treatment options, success rates remain highly …

Ulcerative colitis (UC) is a challenging inflammatory disease with higher relapse and lower remission rates, urgently requiring effective and safe complementary treatment options. Apigenin (Api), a natural flavonoid from parsley and celery,…

OBJECTIVE: To explore the correlation between autoantibodies, ultrasonic endometrial receptivity parameters and early miscarriage in recurrent spontaneous abortion (RSA) patients during subsequent pregnancies, and to establish and validate …

BACKGROUND AND OBJECTIVE: Poly(ADP-ribose) polymerase inhibitors (PARPis) have fundamentally changed the treatment paradigm for patients with ovarian cancer, especially in tumors with homologous recombination deficiency (HRD). However, acqu…

Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor. In this study, we report that platelet-derived …

BACKGROUND: In clinical practice, repeated oocyte retrieval cycles are often necessary for patients with diminished ovarian reserve (DOR). It has been hypothesized that the mechanical stimulation from the initial oocyte pick-up (OPU) proced…

Yang Jin,1,* Yongchao Pan,2,* Yilai Bao,1 Fei Xu,1 Yun Yang,1 Jingwen Fan,1 Yidan Jin,1 Yong Zhou,1 Ruijin Wu1,3 1Department of Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang,…

OBJECTIVE: Women with premenstrual disorder (PMD) display heightened sensitivity to hormonal changes and may be at risk for psychiatric disorders during other hormonally dynamic periods such as pregnancy and postpartum. While PMD has been l…

Ultraviolet (UV) radiation is a primary environmental factor responsible for skin photodamage, and exposure to UV rays is strongly linked to a variety of skin diseases. This study examined the prophylactic and therapeutic effects of Seed Oi…

BACKGROUND: The impact of the interval between consecutive testicular sperm aspiration (TESA) procedures on pregnancy outcomes of intracytoplasmic sperm injection (ICSI) in patients with obstructive azoospermia (OA) remains controversial. T…

OBJECTIVE: To describe the short-term safety, procedural characteristics, and clinical outcomes of ovarian vein embolization with adjunctive local sclerotherapy in a selected subgroup of women with pelvic venous disorder presenting with vul…

During spaceflight, the female reproductive system undergoes substantial adaptation to microgravity and faces an increased risk of reproductive impairment. Mammalian oocytes remain arrested for extended periods at the first meiotic prophase…

This systematic review and Bayesian network meta-analysis assessed the diagnostic accuracy of wearable digital technology (WDT) in monitoring women's fertility window compared to conventional methods. 8 databases were searched until January…

OBJECTIVES: To evaluate the efficacy of gonadotropin-releasing hormone agonist (GnRHa) combined with lauromacrogol sclerotherapy in preserving ovarian reserve and reducing pain in patients with ovarian endometriotic cysts (OECs). MATERIALS…

BACKGROUND: Ureteral reimplantation (UR) is the standard treatment for distal ureteral stricture, yet postoperative anastomotic restenosis impairs outcomes, with conventional imaging unable to quantify urinary tract obstruction and dysfunct…

Endometriosis (EMS) is characterised by a disrupted peritoneal immune microenvironment where M2 macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-seq (ScRNAseq) of the peritoneal macrophages from EMS…

Background and Objective: The ultrasound sliding sign dynamically assesses pouch of Douglas (POD) obliteration in suspected endometriosis. Transvaginal (TVS) and transrectal (TRS) ultrasound are used in patients with and without a self-repo…

Various cellular processes, such as DNA repair and signal transduction, are regulated through ubiquitination and deubiquitination. Dysregulation of ubiquitination cascade enzymes and deubiquitinating enzymes leads to various diseases. Among…

Mitochondrial dysfunction has been implicated in the pathophysiology of endometriosis, but the role of ubiquitin-specific protease 2 (USP2) remains unclear. This study aimed to determine whether USP2 modulates mitochondrial respiratory acti…

BACKGROUND: The benefit of adjuvant chemotherapy for stage I ovarian endometrioid carcinoma (OEC) remains controversial. Hence, the study sought to explore its value in stage I OEC patients. METHODS: Stage I OEC patients (1988-2018) were i…

Ovarian cancer (OC) remains a highly lethal gynecologic malignancy characterized by substantial molecular heterogeneity and diagnostic challenges. Although many reviews examine specific aspects of OC biology or treatment, few attempt to con…

To identify the factors affecting adverse reproductive outcomes in TPOAb-positive patients and to establish a predictive model based on these factors to assess the risk of adverse reproductive outcomes in patients. A retrospective cohort st…