Chen X

BackgroundThe single-incision laparoscopic cholecystectomy (SILC) achieves a scarless appearance through a single umbilical approach. However, the restricted surgical field of view, frequent instrument collisions limit its clinical applicab…

BACKGROUND: Endometrial receptivity (ER) serves as a critical determinant for successful embryo implantation, yet its molecular complexity and limited clinical assessment methods pose significant challenges. Despite advancements in assisted…

Gastric metastasis from breast cancer (GMBC) is a rare but diagnostically challenging condition, whose clinical and imaging features often mimic primary gastric cancer or treatment-related adverse effects. This study integrates a detailed c…

BackgroundSteroid hormone-driven endometrial decidualization involves the differentiation of endometrial stromal cells into decidual cells, which form the decidua for blastocyst implantation. This process is a prerequisite for successful em…

Ferroptosis, characterized by lipid peroxidation and iron-dependent oxidative damage, is a crucial factor in various diseases. Although researchers have extensively characterized ferroptosis in cancer and neurodegenerative disorders, its in…

BackgroundOvarian and endometrial cancers together account for nearly 10% of all female cancer-related deaths worldwide, with ovarian cancer being the deadliest gynecologic malignancy. We aimed to evaluate the diagnostic performance of gene…

Uterine leiomyomas, or fibroids, are the most common benign tumors in women. Despite this, the patient and healthcare burdens are immense. Symptoms include heavy and irregular bleeding, anemia, and impacts on fertility. Treatment options ar…

Pregnant women undergoing assisted reproductive technology (ART) have an increased risk of gestational diabetes mellitus (GDM), potentially linked to altered immune regulation, but the underlying circulating immune features remain unclear. …

Polycystic ovary syndrome (PCOS) exacerbated by obesity represents a complex intersection of endocrine and immune dysregulation, significantly impairing reproductive and metabolic health. This characterizes the immune-inflammatory landscape…

BackgroundPatients undergoing total laparoscopic hysterectomy (TLH) commonly experience postoperative pain and are at relatively high risk of postoperative nausea and vomiting (PONV). Tegileridine is a recently developed biased μ-opioid rec…

Filamentous fungi exhibit high heavy metal resistance; elucidating their resistance mechanisms is of practical importance for fungal utilization and for engineering other microorganisms. However, the molecular basis of copper tolerance in f…

Cancer can educate platelets by altering transcriptome profiles. However, the exact education mechanism remains unclear, and the variability of tumor-educated platelet (TEP) transcriptome has not been investigated. In this study, we aimed t…

This study aimed to investigate the pathogenic mechanisms of jaw cysts by screening for differentially expressed proteins in the tissues of patients with jaw cysts using proteomic techniques. Tissue samples were collected from 4 patients wi…

Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women and severely impairs fertility. Extant clinical studies can only provide indirect and plausible evidence to support endometrial dysfunction as an ova…

β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …

STUDY OBJECTIVE: To explore the associations between adenomyosis patterns on transvaginal sonography (TVS) and surgical outcomes. DESIGN: A retrospective cohort study. SETTING: Peking Union Medical College Hospital, Beijing, China. PATIE…

Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body or introduced through dietary sources a…

Thin endometrium is one of the main factors leading to infertility and miscarriage. The development of biomaterial technology and its clinical applications have shown good effects in promoting endometrial regeneration, improving blood flow,…

In the treatment of ulcerative colitis (UC), persistent inflammatory activity increases the risk of recurrence and poor prognosis. Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional …

Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains unc…

OBJECTIVES: Obesity and endometriosis are intricately linked. The body mass index (BMI) is commonly used as an indicator of obesity, but it has limitations. The visceral adiposity index (VAI) is a novel, low-cost composite index that reflec…

Air pollution has reproductive toxicity, while green space could lessen such harmful consequences. However, the current research on the link between air pollution/green space, and endometriosis remains scarce. Therefore, we investigated the…

BackgroundSpontaneous abortion has been associated with higher risk of type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM), while the evidence remains equivocal. This study aimed to examine the association between sponta…

BACKGROUND: Urinary tract endometriosis (UTE) is a special type of endometriosis affecting the urinary system, yet the physical and mental health of UTE patients remain unexplored. METHODS: We enrolled 92 women with UTE and another 234 wit…

BackgroundTo a large extent, the ovarian reserve determines a woman's reproductive potential. The etiological and pathological mechanisms of diminished ovarian reserve (DOR) remain unclear, and no reliable treatment is currently available f…