Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis [Response to Letter]

Shi W, Wang M, Jin Z, Chen X, Li J, Lai H, Li X, Zhong Q, Chen Y, Chen S
In: Journal of Pain Research, Vol Volume 19, Iss Issue 1, Pp 1-2 (2026) · 2026 · W7154870704
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Metabolomics analysis reveals that gut microbiota-associated sakuranin modulates endometrial stem cell differentiation and inflammation to alleviate pain in endometriosis.

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This response to a letter details how gut microbiota-associated sakuranin alleviates pain in endometriosis by modulating endometrial stem cell differentiation and reducing inflammation. The authors utilized metabolomics analysis to identify the mechanisms through which sakuranin exerts these therapeutic effects on endometrial tissue. The paper explicitly states that sakuranin targets specific inflammatory pathways and stem cell behaviors relevant to the pathophysiology of the disease. This paper is centrally about endometriosis — specifically investigating the role of gut microbiota-derived metabolites in pain modulation and stem cell regulation within endometrial lesions.

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Abstract

Wen Shi,1–3,* Minyi Wang,1–3,* Zhuang Jin,1–3 Xiaochuan Chen,1–3 Jinbo Li,1–3 Huiling Lai,1–3 Xiao Li,1–3 Qiyu Zhong,1–3 Ye Chen,1–3 Shuqin Chen1–3 1Department of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, People’s Republic of China; 3Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuqin Chen, Department of Gynecology, Block B, 12th Floor, Building 1, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26, Yuancun Erheng Road, Tianhe District, Guangzhou, Guangdong, 510655, People’s Republic of China, Tel +86-13825039699, Email [email protected]
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Journal of Pain Research (Apr 2026) Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis [Response to Letter] Abstract Wen Shi,1–3,* Minyi Wang,1–3,* Zhuang Jin,1–3 Xiaochuan Chen,1–3 Jinbo Li,1–3 Huiling Lai,1–3 Xiao Li,1–3 Qiyu Zhong,1–3 Ye Chen,1–3 Shuqin Chen1–3 1Department of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, People’s Republic of China; 3Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuqin Chen, Department of Gynecology, Block B, 12th Floor, Building 1, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26, Yuancun Erheng Road, Tianhe District, Guangzhou, Guangdong, 510655, People’s Republic of China, Tel +86-13825039699, Email [email protected]

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