Zhang M

Endometriosis (EMs) affects the physical and mental health of a wide range of women of childbearing age. Exploring specific diagnostic targets and screening potential therapeutic drugs will help early diagnosis and improve prognosis. The di…

BACKGROUND: Pyroptosis has been reported to occur in several diseases, such as atherosclerosis, nonalcoholic steatohepatitis, and endometriosis. Although fucoxanthin has several biological properties (particularly anti-inflammatory properti…

BackgroundThe ovary is a vital and dynamic reproductive organ. Ovarian tissue cryopreservation (OTC) plays a vital role in preserving female fertility. However, the cellular subtypes most susceptible to cryoinjury and the molecular mechanis…

PROBLEMS: To investigate the impact of anti-endometrial antibodies (EMAb) on pregnancy outcomes in infertile patients undergoing in vitro fertilization (IVF) and to assess the potential value of personalized treatment strategies. METHOD OF…

BackgroundChronic endometritis (CE), characterized by CD138+ plasma cell infiltration, has been proposed to impair reproductive outcomes in assisted reproductive technology (ART). However, current evidence remains inconsistent, and diagnost…

Urological malignancies represent a group of highly aggressive tumors with a strong tendency toward therapy resistance. Their pathogenesis is closely associated with metabolic reprogramming and epigenetic regulation. In recent years, lactyl…

MicroRNA-17(miR-17) is a prototypical oncogenic miRNA that plays a central driving role in the initiation and progression of various malignant tumours (MT), including lymphoma, lung cancer, colorectal cancer (CRC), and breast cancer (BC). I…

The MYC family has been the subject of extensive research in the field of cancer, yet the mechanisms by which these factors operate in the context of endometriosis remain unclear. Considering the existing studies on the MYC family and disea…

BACKGROUND AND PURPOSE: Endometriosis is a chronic, hormone-dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is eff…

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone proteins. This modif…

Acute pancreatitis is a complex inflammatory disease with high morbidity and mortality, closely associated with intestinal barrier dysfunction, gut microbiota dysbiosis and abnormal lipid metabolism. Akkermansia muciniphila has been shown t…

Y-box binding protein 1 (YBX1) has been reported to play a role in human granulosa cell (GC) dysfunction by binding with long noncoding RNAs in patients with primary ovarian insufficiency (POI). 5-Methylcytosine (m5C) methylation is an abun…

AbstractThis retrospective study investigated factors associated with abnormal endometrial peristaltic waves (EPWs) and evaluated the impact of Atosiban intervention on clinical outcomes in frozen-thawed embryo transfer (FET) cycles. A tota…

Ectopic spleen (ES) is a rare complication of autologous transplant following spleen injury. Autopsy studies suggest that the true incidence rate could be as high as 67%, though only 5%-10% of patients require clinical intervention. This ca…

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successfu…

Musculoskeletal ultrasound has gained increasing attention as a noninvasive imaging modality in pain clinics. Its advantages include the lack of radiation exposure, cost-effectiveness, and efficiency, allowing for rapid provision of dynamic…

The relationship between hyperprolactinemia and gut microbiota remains unclear at present. This study employs a Mendelian randomization (MR) approach to assess the potential causal links between gut microbiota and the incidence of hyperprol…

Infertility is a prevalent reproductive disorder, with local and systemic inflammatory responses potentially playing a pivotal role in its etiology. Alpha-1-acid glycoprotein (AGP), an acute-phase glycoprotein, has been implicated in inflam…

Study questionDo novel per- and poly-fluoroalkyl substances (Novel PFAS) have associations with premature ovarian insufficiency (POI)?Summary answerHexafluoropropylene oxide dimer acid (HFPO-DA), perfluorobutanoic acid (PFBA), perfluoropent…

The incidence of malignant tumors continues to grow. Still, with the rapid development of various diagnostic and therapeutic techniques, the survival rate of malignant tumors has been improved, and the increased survival rate has introduced…

BackgroundGrowing evidence suggests that environmental pollutants exert a detrimental impact on female fertility. Among these pollutants, volatile organic compounds (VOCs), easily encountered in the environment, have garnered significant at…

Leiomyomas (LM) and adenomyosis (AM) are common gynecological diseases with high incidence rates and an increasing trend of affecting younger women. Accurate detection and differentiation of LM and AM in ultrasound images are crucial for se…

Sequelae of pelvic inflammatory disease (SPID), such as chronic pelvic pain and infertility, are major long-term complications that significantly harm women's health. N6-methyladenosine (m6A), the most common internal mRNA modification in e…

OBJECTIVE: This study aimed to investigate the mechanism of the involvement of USP33 in autophagic ferroptosis in endometriosis (EMs). METHODS: Endometrial stromal cells (ESCs) were isolated from 15 healthy controls and 30 patients with EM…