Magdy P. Milad

OBJECTIVE: To characterize gynecology clinical trials over time, compare gynecology subspecialties, and analyze factors associated with early discontinuation, results reporting, and publication. METHODS: We conducted a cross-sectional anal…

This study aimed to explore the performance of ChatGPT version 4.0 (GPT-4) and Gemini Advanced (Gemini) large language models (LLMs) in addressing common patient questions after gynecology surgery with regards to accuracy, relevance, helpfu…

PURPOSE OF REVIEW: Atypical endometriosis is a distinct subtype of endometriosis, characterized by specific histopathologic findings. It is thought to be a precursor lesion to endometriosis-associated ovarian cancers, particularly clear-cel…

BACKGROUND: Female Chronic Pelvic Pain (CPP) is a common, complex, and multifactorial disease that is associated with a number of non-gynecologic and gynecologic conditions. The physical symptoms associated with CPP can contribute to emotio…

INTRODUCTION: While it is well known that endometriosis places a significant burden on both patients and our healthcare system, there remains a poor understanding of how the clinical variability of endometriosis impacts this burden. Patient…

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into t…

PURPOSE OF REVIEW: Use of patient-reported outcome measures in clinical practice and research is becoming more prevalent and reflects initiatives to center the patient in healthcare delivery and outcomes assessment. The purpose of this revi…

PURPOSE OF REVIEW: Adenomyosis is commonly diagnosed in women of reproductive age. Interest in conservative interventions has grown as more women desire fertility preservation or avoidance of hysterectomy. This review discusses surgical and…

OBJECTIVE: To present a unique case of pelvic pain. DESIGN: Case report. SETTING: Academic institution. PATIENT(S): Thirty-nine year-old with history of endometriosis presented with pelvic pain and possible adnexal mass. INTERVENTION(S)…

CONTEXT: Retinoic acid (RA) controls multiple biological processes via exerting opposing effects on cell survival. Retinol uptake into cells is controlled by stimulated by RA 6 (STRA6). RA is then produced from retinol in the cytosol. Parti…

CONTEXT: Estradiol and its nuclear receptors, estrogen receptor (ER) alpha and ERbeta, play critical roles in endometrium and endometriosis. Levels of ERbeta, due to pathological hypomethylation of its promoter, are significantly higher in …

Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue endometriosis play critical physiologic roles. We found that mRNA and protein levels of estrogen receptor 2 (ESR2) were strikingly higher, whereas leve…

CONTEXT: Endometriosis is an estrogen-dependent disease. Steroidogenic factor-1 (SF-1), a transcriptional factor essential for activation of multiple steroidogenic genes for estrogen biosynthesis, is undetectable in normal endometrial strom…

STUDY OBJECTIVE: To identify risk factors and short-term outcomes associated with conversion from laparoscopic surgery to laparotomy. DESIGN: Case control study (Canadian Task Force classification II-2). SETTING: Large urban, academic med…