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Study questionDoes adjuvant letrozole in ovarian stimulation for IVF decrease the uterine peristalsis frequency (UPF) prior to fresh embryo transfer (ET)?Summary answerAdjuvant letrozole in ovarian stimulation for IVF does not reduce the UP…
BackgroundThe use of peri-implantation glucocorticoids has been advocated to improve embryo implantation during assistive reproductive technology (ART) cycles such as in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). …
The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe …
Study questionAre live birth rates (LBRs) after artificial cycle frozen-thawed embryo transfer (AC-FET) non-inferior to LBRs after modified natural cycle frozen-thawed embryo transfer (mNC-FET)?Summary answerAC-FET is non-inferior to mNC-FE…
Study questionDo the amino acid levels of human uterine fluid vary with age, BMI, phase of menstrual cycle, benign pathology or diet?Summary answerThe levels of 18 amino acids in human uterine fluid were shown to be affected only by materna…
Background'Omics' high-throughput analyses, including genomics, epigenomics, transcriptomics, proteomics and metabolomics, are widely applied in human endometrial studies. Analysis of endometrial transcriptome patterns in physiological and …
STUDY QUESTION: How do the expression patterns of neuronal markers differ in the endometrium of women with and without endometriosis? SUMMARY ANSWER: The neuronal markers, PGP9.5, NGFp75 and VR1, are expressed in the endometrium at levels …
BACKGROUND Mechanisms underlying early reproductive loss in the human are beginning to be elucidated. The migratory and invasive capacity of human endometrial stromal cells (ESCs) is increasingly recognized to contribute to the intense tiss…
BackgroundLong-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies are unknown.MethodsWe identified a nationwide historic cohort of 19,146 women who received IVF treatment in the Netherlands between 1983 and 1995…
BACKGROUND: In the Netherlands, 30% of subfertile women are overweight or obese, and at present there is no agreement on fertility care for them. Data from observational and small intervention studies suggest that reduction of weight will i…
PurposeTo calculate the added benefit of a cryopreservation program to the cumulative ongoing pregnancy rate over a maximum of three cycles of IVF.MethodsA total of 1251 couples beginning their first IVF treatment between January 1995 and D…