Wang C

OBJECTIVE: To explore barriers affecting medication adherence (e.g., missed doses, forgotten doses, or discontinuation) among patients with Ovarian Endometriosis (OE) using the Capability, Opportunity, Motivation - Behaviour (COM-B) behavio…

Endometrial cancer (EC) encompasses various histological and molecular subtypes, each with unique immune, endocrine and metabolic characteristics, resulting in varying responses to treatment. Although immunotherapy, endocrine therapy and me…

Introduction and aimsOral squamous cell carcinoma (OSCC) is a common malignant tumour of the head and neck region. In recent years, the relationship between pyroptosis and tumours has received increasing attention. However, its regulatory m…

Objective: To investigate the differences in clinicopathological and molecular characteristics between pure ovarian endometrioid carcinoma (POEC) and synchronous endometrial and ovarian endometrioid carcinoma (SEOEC), aiming to provide a ba…

BackgroundTo compare the efficacy of modified gonadotropin-releasing hormone (GnRH) antagonist protocols combining clomiphene citrate (CC) or letrozole (LE) versus a conventional antagonist protocol in patients with normal ovarian reserve, …

ObjectiveTo analyze the correlation between lipid levels and the severity of polycystic ovary syndrome (PCOS) and its predictive value for pregnancy outcome.MethodsThis retrospective study included 275 PCOS patients treated with ovulation i…

STUDY QUESTION: How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches? SUMMARY ANSWER: This exploration of the gut-reproductive axis in patients with endometriosis found…

BACKGROUND: Endometriosis (EMs) is a common gynaecological condition with high recurrence rates after fertility-preserving laparoscopic surgery, and optimal postoperative medical treatment remains unclear. OBJECTIVES: To evaluate the effic…

INTRODUCTION: The objective of this study was to examine the impact of semaphorin 3F (SEMA3F) on the proliferation, migration and ferroptosis of endometrial stromal cells in patients with endometriosis (EMS). METHODS: This study collected …

Primary dysmenorrhea is currently an unresolved public health problem worldwide, which suffers the patients comprehensive symptoms. Currently, more and more studies have been focusing on biomarker exploration for diagnosis and target therap…

PurposeAcute pancreatitis is a common disease with limited supportive treatments. Finding effective biomarkers is of great significance for early diagnosis and therapy, as well as to achieve better prognosis.Materials and methodsThe core ge…

ObjectiveTo compare the effects of frozen-thawed embryo transfer at different times after hysteroscopic endometrial polyp resection on pregnancy outcomes and to provide evidence for individualized clinical treatment.MethodsThis study was a …

BackgroundCervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood.MethodsIn this study, we performed an…

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by reproductive and metabolic disturbances, which causes a chronic lack of ovulation that leads to increased incidence of atypical endometrial hyperplasia and …

Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor. In this study, we report that platelet-derived …

STUDY OBJECTIVE: To evaluate the predictive value of preoperative triple pelvic examination combined with transvaginal sonography (TVS) for posterior pelvic deep endometriosis (DE). DESIGN: A prospective randomized controlled clinical stud…

The study explored the mechanism of Dan'e-fukang soft extract in treating endometriosis (EMs) through network pharmacology. The main active ingredients of Dan'e-fukang soft extract were analyzed based on the traditional Chinese medicine sys…

This study aims to explore the application value of stromal cell-derived factor (CXCL12), vascular endothelial growth factor (VEGF) and carbohydrate antigen 125 (CA125) in the diagnosis, staging, and clinical manifestations of endometriosis…

Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic, each with distinct biopsychosocial mechanisms. Chronic pain was historically viewed as a mo…

BackgroundImmature teratoma is a malignant tumor and accounts for 1%-3% of ovary teratoma. The objective of this study was to find the potential single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and drug targets in the i…

BackgroundPolycystic ovary syndrome (PCOS) is widely acknowledged as the prevailing reproductive endocrine disorder accompanied by numerous metabolic dysfunctions. However, there has been a lack of systematic examination regarding the amino…

PurposeThis study aims to assess the impact of ultrasound parameters on endometrial receptivity in patients undergoing IVF-ET and to establish a predictive model for ongoing pregnancy outcomes.MethodsThe prospective cohort study included 86…

High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign samples to balanced batches, m…