Margherita Rossi

No ORCID on file · 9 papers in corpus · active 2022-2025

Study types

  • article 5
  • other 2
  • review 2

Condition tags

  • endometriosis 5
  • infertility 3
  • adenomyosis 3
  • dysmenorrhea 1
  • endometrioma 1
  • die_deep_infiltrating 1
other 2025
Generation of epithelial-stromal assembloids as an advanced in vitro model of impaired adenomyosis-related endometrial receptivity
Fertility and sterility ·doi:10.1016/j.fertnstert.2024.08.339

OBJECTIVE: To create a novel, more advanced in vitro model of human endometrium, using so-called assembloids, looking to explore endometrial receptivity in adenomyosis. DESIGN: Evaluation of assembloid responsiveness to hormonal stimulatio…

article 2024
Imaging and molecular features of adenomyosis after menopause
Maturitas ·doi:10.1016/j.maturitas.2024.107996

OBJECTIVES: To explore the imaging features and the molecular characterization of adenomyosis after menopause. STUDY DESIGN: An observational cross-sectional study was performed in a group of postmenopausal patients undergoing a transvagin…

article 2024
Refining endometrial assembloids: a novel approach to 3-dimensional culture of the endometrium
·doi:10.1016/j.xfss.2024.08.005

Enhancing the efficacy of three-dimensional endometrial assembloid models is pivotal for deepening our comprehension of endometrial physiology. We investigated the optimal ratio of organoids to stromal cells in these models, utilizing human…

other 2024
Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced invasive phenotype of endometriotic cells
The FEBS journal ·doi:10.1111/febs.17071

Endometriosis is a chronic gynecological syndrome characterized by endometrial cell invasion of the extra-uterine milieu, pelvic pain and infertility. Treatment relies on either symptomatic drugs or hormonal therapies, even though the mecha…

article 2023
Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis
Vitamins and hormones ·doi:10.1016/bs.vh.2023.01.007

Endometriosis is a benign gynecological disease affecting ∼10% of reproductive-aged women and is defined as the presence of endometrial glands and stroma outside the uterine cavity. Endometriosis can cause a variety of health problems, from…

article 2023
Sphingosine-1-phosphate receptor 3 is a non-hormonal target to counteract endometriosis-associated fibrosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.12.007

OBJECTIVE: To study the molecular mechanisms responsible for fibrosis in endometriosis by investigating whether the protein expression levels of sphingosine-1-phosphate receptor 3 (S1PR3), one of the five specific receptors of the bioactive…

review 2022
Hormonal drugs for the treatment of endometriosis
Current opinion in pharmacology ·doi:10.1016/j.coph.2022.102311

In the past, the primary approach for the treatment of endometriosis was represented by surgery; however, after the introduction of non-invasive diagnosis of endometriosis with the development of imaging technologies, medical treatment beca…

review 2022
Hormonal treatments for endometriosis: The endocrine background
Reviews in endocrine & metabolic disorders ·doi:10.1007/s11154-021-09666-w

Endometriosis is a benign uterine disorder characterized by menstrual pain and infertility, deeply affecting women's health. It is a chronic disease and requires a long term management. Hormonal drugs are currently the most used for the med…

article 2022
Mechanisms and Pathogenesis of Adenomyosis
·doi:10.1007/s13669-022-00326-7

Abstract Purpose of the Review The purpose of this review is to provide a synopsis of all the mechanisms involved in the pathogenesis of adenomyosis. It will summarize recent advances in the field, discussing current controversies, and cons…