Allen-Brady K

ContextAutoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.ObjectiveWe hypothesized that a subset …

BackgroundNonobstructive azoospermia (NOA) and primary ovarian insufficiency (POI) have common genetics that may also predispose patients to cancer risk.ObjectivesWe hypothesized that NOA or severe oligozoospermia and the risk of male cance…

ContextDNA damage/repair gene variants are associated with both primary ovarian insufficiency (POI) and cancer risk.ObjectiveWe hypothesized that a subset of women with POI and family members would have increased risk for cancer.DesignCase-…

IMPORTANCE: Endometriosis has been associated with an increased risk of ovarian cancer; however, the associations between endometriosis subtypes and ovarian cancer histotypes have not been well-described. OBJECTIVE: To evaluate the associa…

Study questionHow does the number of children in women with primary ovarian insufficiency (POI) compare to the number for control women across their reproductive lifespans?Summary answerApproximately 14% fewer women with POI will have child…

ObjectiveTo determine the familiality of primary ovarian insufficiency (POI) at population level through examination of multigenerational genealogical information linked to electronic medical records.DesignCase-control study.SettingNot appl…

BACKGROUND: Women with endometriosis may have an increased risk of adverse pregnancy outcomes. Research has focused on infertility clinic populations limiting generalisability. Few studies report differences by endometriosis severity. OBJE…

BACKGROUND: Caffeine, alcohol, smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone-dependent gynaecologic disease risk, such as endometriosis; however, few studies have assessed life style factor…

ObjectivesUrological chronic pelvic pain syndrome includes interstitial cystitis/painful bladder syndrome (IC/PBS), a chronic bladder pain condition of unknown etiology. Interstitial cystitis/painful bladder syndrome can co-occur with a num…