Welt CK

ContextAutoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.ObjectiveWe hypothesized that a subset …

BackgroundNonobstructive azoospermia (NOA) and primary ovarian insufficiency (POI) have common genetics that may also predispose patients to cancer risk.ObjectivesWe hypothesized that NOA or severe oligozoospermia and the risk of male cance…

ContextDNA damage/repair gene variants are associated with both primary ovarian insufficiency (POI) and cancer risk.ObjectiveWe hypothesized that a subset of women with POI and family members would have increased risk for cancer.DesignCase-…

Study questionHow does the number of children in women with primary ovarian insufficiency (POI) compare to the number for control women across their reproductive lifespans?Summary answerApproximately 14% fewer women with POI will have child…

BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous disorder because of the variable criteria used for diagnosis. Therefore, International Classification of Diseases 9 (ICD-9) codes may not accurately capture the diagnostic criter…