Rocca WA

OBJECTIVES: To determine the risk of developing de novo carpal tunnel syndrome (CTS), arthritis, or rheumatoid arthritis in women who underwent hysterectomy with bilateral ovarian conservation (H-OC) before reaching spontaneous menopause. …

IntroductionPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.MethodsFemale participants …

OBJECTIVE: There is limited information on the prevalence of premature and early menopause. Therefore, we studied the frequency and type of premature (age < 40 years) or early (age 40-44 years) menopause in a geographically-defined American…

ObjectiveWe examined the long-term effects of premenopausal bilateral oophorectomy (PBO) with or without concurrent or preceding hysterectomy on physical and cognitive function and on odds of chronic conditions.MethodsWe enrolled 274 women …

ImportanceThe association of premenopausal bilateral oophorectomy with parkinsonism and Parkinson disease (PD) remains controversial.ObjectiveTo assess whether women who underwent premenopausal bilateral oophorectomy were at increased risk …

ObjectiveTo evaluate trends in the incidence of premenopausal unilateral and bilateral oophorectomy between 1950 and 2018.MethodsThe Rochester Epidemiology Project medical records-linkage system was used to identify all women aged 18-49 yea…

ObjectiveTo study the trajectories of metabolic parameters after bilateral oophorectomy.Study designThis population-based cohort study included a random sample of all premenopausal women who underwent bilateral oophorectomy at or before age…

ImportanceThe associations of bilateral oophorectomy among premenopausal women, age at oophorectomy, and use of estrogen therapy after oophorectomy with cognitive performance later in life remain controversial.ObjectiveTo investigate whethe…

ImportanceRestless legs syndrome is a common neurologic disorder that is more prevalent in women than in men, and it has been suggested that female hormones may be involved in the disorder's pathophysiology.ObjectiveTo determine whether wom…

In this invited review, we discuss some unresolved and controversial issues concerning premature (<40 years) or early (40-45 years) bilateral oophorectomy. First, we clarify the terminology. Second, we summarize the long-term harmful conseq…

ObjectiveThe incidence of carpal tunnel syndrome (CTS) is higher in women, and peaks around the age of menopause. Therefore, we investigated whether bilateral oophorectomy is associated with an increased risk of severe CTS.MethodsWe include…

ObjectiveWe studied eight mental health conditions diagnosed before bilateral oophorectomy performed for nonmalignant indications.MethodsWe identified 1,653 premenopausal women who underwent bilateral oophorectomy for a nonmalignant indicat…

Background and objectivesPremenopausal women who undergo bilateral oophorectomy are at a higher risk of morbidity and mortality. Given the potential benefits of estrogen on kidney function, we hypothesized that women who undergo bilateral o…

Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cel…

ObjectivesWe investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population.Study designIn an established cohort study, we used the …

BackgroundThe cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy.MethodsThe Rochester Epidemiology Project records-linkage syst…

ObjectiveTo study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity.Patients and methodsIn this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to ident…

OBJECTIVE: This study aims to determine the association of preexisting cardiovascular risk factors and cardiovascular diseases with hysterectomy with bilateral ovarian conservation using a case-central design. METHODS: Using the Rochester E…

OBJECTIVE: Unilateral oophorectomy (UO) is a common surgical practice, yet it remains understudied. We investigated trends in incidence rates, indications, and pathological differences in the right and left ovaries in women younger than 50 …

The neuroprotective effects of estrogen have been demonstrated consistently in cellular and animal studies but the evidence in women remains conflicted. We explored the window of opportunity hypothesis in relation to cognitive aging and dem…

ObjectiveTo investigate the mortality associated with cardiovascular diseases and the effect of estrogen treatment in women who underwent unilateral or bilateral oophorectomy before menopause.DesignWe conducted a cohort study with long-term…

In the Mayo Clinic Cohort Study of Oophorectomy and Aging, women who had both ovaries removed before reaching natural menopause experienced a long-term increased risk of parkinsonism, cognitive impairment or dementia, and depressive and anx…