Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Rocca WA; Gazzuola Rocca L; Smith CY; Grossardt BR; Faubion SS; Shuster LT; Kirkland JL; LeBrasseur NK; Schafer MJ; Michelle M. Mielke; Kantarci K; Stewart EA; Miller VM

doi:10.1152/physiol.00024.2018

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Michelle M. Mielke, Kantarci K, Stewart EA, Miller VM

Physiology (Bethesda, Md.) · 2018 · doi:10.1152/physiol.00024.2018 · PMID:30303778 · PMC6734081

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-09 ⓘ

Bilateral oophorectomy causes premature loss of ovarian hormones, accelerating somatic and mental aging processes across multiple biological levels and leading to multimorbidity and reduced survival.

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Abstract

Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.

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