Michelle M. Mielke

IntroductionPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.MethodsFemale participants …

Abstract Restless legs syndrome (RLS), a common neurologic disorder, is more prevalent in women than in men. Evidence indicates the potential role of female hormones in the pathophysiology of RLS. However, few studies have examined the rela…

Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cel…

ObjectivesWe investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population.Study designIn an established cohort study, we used the …

PurposeThis cohort study was established to investigate the effects of unilateral and bilateral oophorectomy on the ageing processes in women.ParticipantsWe used the records-linkage system of the Rochester Epidemiology Project (REP, http://…

Sphingomyelin metabolism has been linked to several diseases and to longevity. However, few epidemiological studies have quantified individual plasma sphingomyelin species (identified by acyl-chain length and saturation) or their relationsh…