Chang-Hai Tsai — Endo Lab

article 2008

XRCC4 codon 247*A and XRCC4 promoter −1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis

Molecular reproduction and development ·doi:10.1002/mrd.20829

DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. Genetic variants in DNA repair genes such as X-ray repair cross-complementing group 4 (XRCC4) m…

article 2007

Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis.

The Chinese journal of physiology

Endometriosis shows some characteristics of malignancy, including local invasion and aggressive spread to distant organs. The pathology of endometriosis may involve a complex interaction among genetic defects, DNA repairing defects and envi…

article 2005

Estrogen receptor α dinucleotide repeat and cytochrome P450c17α gene polymorphisms are associated with susceptibility to endometriosis

Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.07.977

ObjectiveTo investigate the association of endometriosis with estrogen receptor alpha (ER alpha) and cytochrome P450c17alpha (CYP17) gene polymorphisms in light of the fact that estrogen plays a role in the pathogenesis of endometriosis and…

article 2005

Interleukin-2 receptor β (IL-2Rβ)-627*C homozygote but not IL-12Rβ1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis

Fertility and sterility ·doi:10.1016/j.fertnstert.2005.02.025

Interleukin (IL)-2 R-627*C homozygote and C allele are related to higher susceptibility to endometriosis. Interleukin-12Rbeta1 codon 378 and IL-18 105 gene polymorphisms are not correlated with endometriosis development.

article 2005

T homozygote and allele of epidermal growth factor receptor 2073 gene polymorphism are associated with higher susceptibility to endometriosis and leiomyomas

Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.08.032

Epidermal growth factor receptor (EGFR) is a regulator of angiogenesis and mediator of sex steroid-induced cell growth and differentiation. We observed that EGFR gene 2073*T-related genotypes and allele are associated with higher susceptibi…

article 2004

Angiotensin I-converting enzyme ACE 2350*G and ACE-240*T-related genotypes and alleles are associated with higher susceptibility to endometriosis

Molecular human reproduction ·doi:10.1093/molehr/gah131

Endometriosis displays features similar to malignancy, ranging from neovascularization to local invasion and aggressive spread to distant organs. The altered vascular-related genes might be related to the development of endometriosis. This …

other 2004

Cytochrome P450c17alpha 5'-untranslated region *T/C polymorphism in endometriosis

Journal of genetics ·doi:10.1007/BF02729896

Estrogen plays a role in the pathogenesis of endometriosis. The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the estrogen biosynthesis. We aimed to investigate if CYP17 polymorphism could be used as marker to …

other 2004

Glutathione S-transferase M1*null genotype but not myeloperoxidase promoter G-463A polymorphism is associated with higher susceptibility to endometriosis

Molecular human reproduction ·doi:10.1093/molehr/gah095

Glutathione S-transferase M1 (GSTM1), one member of the GST family, is responsible for metabolism of xenobiotics and carcinogens. Myeloperoxidase (MPO) plays an important role in the oxidation and activation of carcinogens and nitric oxide.…

other 2002

Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: non-association with endometriosis

Journal of clinical laboratory analysis ·doi:10.1002/jcla.10021

Interleukin-4 (IL-4) is a cytokine with anti-inflammatory properties. Tumor necrosis factor alpha (TNF-alpha), a pluripotent proinflammatory cytokine, plays an important role in the process of numerous inflammatory and autoimmune diseases. …