Jens Nagel

No ORCID on file · 29 papers in corpus · active 2014-2026

Study types

  • article 16
  • other 6
  • review 4
  • preprint 3

Condition tags

  • endometriosis 25
  • chronic_pelvic_pain 14
  • interstitial_cystitis 6
  • dyspareunia 4
  • dysmenorrhea 2
article 2019
Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.8b01862

The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes-the latter being frequently associated with severe, acute, and chronic p…

article 2018
The Medium-Chain Free Fatty Acid Receptor GPR84 in Endometriosis Associated Pain.

The G-protein coupled receptor GPR84 binds and becomes activated by saturated medium-chain free fatty acids, is expressed on pro-inflammatory macrophages and pharmacological inhibition leads to reduction of inflammatory markers.

article 2015
Dynamic weight bearing as a non‐reflexive method for the measurement of abdominal pain in mice
European journal of pain (London, England) ·doi:10.1002/ejp.800

BACKGROUND: Chronic pelvic pain (CPP) is a high burden for patients and society. It affects 15-24% of women in reproductive age and is an area of high unmet medical need. CPP can be caused by a wide range of visceral diseases such as abdomi…

article 2014
Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat
Journal of neuroscience methods ·doi:10.1016/j.jneumeth.2014.05.017

BackgroundChronic pelvic pain (CPP) is defined as long-lasting and severe pelvic pain persisting over six months in cyclic or non-cyclic chronic manner. Various pathologic conditions like endometriosis, abdominal infections, intra-peritonea…