Sylvia Mechsner

INTRODUCTION: Deep infiltrating endometriosis (DIE) affects between 3.8% and 37% of all endometriosis patients, mostly affecting rectovaginal septum or retrocervical space and characterized by the severe endometriosis-related complaints. No…

Study objectiveBeside the pain, there are 2 further problems in the management of endometriosis: the high recurrence rate (10% per year) and the high rate of impaired fertility. The objective of this study was to investigate the pathogenesi…

Die Adenomyosis uteri (AM) ist ein unterschätztes Problem. Mehr und mehr Daten deuten darauf hin, dass die AM in Endometriose-Patientinnen, neben Beschwerden wie Dys- und Hypermenorrhoe auch Einfluss auf die Fertilität hat und mit Schwanger…

PurposeSuperficial peritoneal endometriotic (pEM) lesions are composed of endometrial glands and stroma, in addition to a third component-myofibroblasts and smooth muscles (SM)-like cells. The latter develops secondary to a metaplasia. In t…

Study objectiveTo evaluate the clinical presentation and surgical outcome in patients with deep lateral pelvic endometriosis (dLPE).DesignA retrospective multicentric study (Canadian Task Force classification II-2).SettingUniversity tertiar…

In this study, we report about a patient with extra-uterine endometriosis (EM) in the abdominal wall muscle with evident metaplasia based on the abundant alpha smooth muscle actin (ASMA)-expressing myofibroblasts. Laparotomy excision of the…

Introduction Endometriosis is associated with both cyclic and non-cyclic pelvic pain. Many patients do not remain symptom free, even after guideline-oriented treatment. This study aimed to identify differences in endometriosis-associated pa…

Pain is the most important symptom in patients with endometriosis, and its management is truly challenging. Due to the different localization of the endometriotic lesions in the pelvis, patients suffer from visceral and somatic pain or both…

BackgroundAdenomyosis (AM) uteri exhibit hyperperistalsis. The latter causes a chronic tissue trauma at the endometrial-myometrial junctional zone (EMJZ). Upon tissue trauma, microdehiscences in the myometrium facilitate the translocation o…

To identify factors influencing the differential pain pathogenesis in peritoneal endometriosis (pEM) and peritoneal carcinomatosis in ovarian cancer (pOC), we undertook an experimental study. Tissue samples of 18 patients with pEM, 15 patie…

The selected endometriosis tissue required the presence of glandular epithelial cells and stromal cells. ROI were developed by selecting â customâ mode applied to separate lumen, epithelial gland tissue and stromal tissue. The lumen ROI was…

Setting parameter for nuclei size. The nucleus size was determined as depicted in Fig. 4a. It was based on blue color detection (hematoxylin staining). Brown color expressed by cell was restricted from interior radius −4,81 μm to exterior r…

Manual counting of nerve fibers. Region of interests were selected randomly and marked with a border to obtain an area of 1Â mm2 each. A single nerve fiber was marked manually by using a tool available in HistoquestÂŽ software. (JPG 565Â kb…

Establishing the diagnostic and surgical management of the inguinal Endometriosis, with further investigation of the biological character.The imaging findings of CT and PET-CT, biopsy, ultrasound, open surgery of the inguinal region with in…

ObjectiveTo identify and characterize endometriosis-associated immune cell infiltrates (EMaICI). Furthermore, to define occurrence and size of EMaICI in various types of endometriosis.MethodsImmune cells were characterized in samples of 60 …

Endometriosis is a chronic disease of women during their reproductive age. The most typical symptoms are dysmenorrhoea, dyspareunia, dysuria, cyclical and acyclical pelvic pain, bleeding disorders and infertility. These symptoms lead to sig…

Die Endometriose als klassische östrogenabhängige Erkrankung hat eine Reihe von Überlebensstrategien entwickelt, die es den ektopen Läsionen ermöglichen, sich zu entwickeln. Als wichtigste Pathogenesefaktoren gelten die von ovariellen Stero…

Study objectiveTo evaluate the feasibility of a novel laparoscopic procedure for complete eradication of diaphragmatic endometriosis (DE).DesignA retrospective multicenter study (Canadian Task Force Classification II-2).SettingUniversity te…

BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related k…

Introduction: Pelvic pain is a common problem in gynaecological practice. It is often unclear whether definite causality exists between reported symptoms and objective clinical findings of the female genital tract, and medical or operative …

STUDY HYPOTHESIS: Loss of protein BAF250a (ARID1A) expression is present in women with rectovaginal deep-infiltrating endometriosis (DIE) and endometriosis affecting the pelvic sentinel lymph nodes (PSLN). STUDY FINDING: Partial loss of pro…