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Condition tags
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- infertility 7
- chronic_pelvic_pain 6
- adenomyosis 6
- dyspareunia 4
- endometrioma 3
- dysmenorrhea 2
- bowel_endometriosis 1
Top journals
Frequent coauthors
- Olivier Donnez 38
- Jacques Donnez 32
- Donnez J 31
- Marie-Madeleine Dolmans 13
- Dolmans MM 12
- Jean-Luc Squifflet 11
- Squifflet J 10
- Pascale Jadoul 7
- Jadoul P 7
- Defrère S 5
INTRODUCTION: A symptomatic uterine niche is a long-term complication after a cesarean section (CS). A group of international niche experts reached consensus on a standardized definition of a disorder caused by a symptomatic niche, named ce…
STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone ac…
BackgroundUterine niches in the Caesarean section scar are seen in approximately half of women with a history of caesarean delivery. Whilst a structured ultrasound assessment of caesarean defects has been described, there is no consensus on…
Cesarean scar disorder (CSD) is an entity recently defined as uterine niche with at least one primary or 2 secondary symptoms. CSDs can be visualized by hysterosalpingography, transvaginal sonography, saline infusion sonohysterography, hyst…
IMPORTANCE: Approximately 60% of women develop a uterine niche after a cesarean delivery (CD). A niche is associated with various gynecological symptoms including abnormal uterine bleeding, pain, and infertility, but there is little consens…
RESEARCH QUESTION: Does a once-daily regimen of linzagolix, a new oral gonadotrophin-releasing hormone (GnRH) antagonist, given at a fully suppressive dose (200 mg) for 12 weeks, followed by a partially suppressive dose (100 mg) for a furth…
Deep endometriosis infiltrating the rectum remains a challenging situation to manage, and it is even more important when ureters and pelvic nerves are also infiltrated. Removal of deep rectovaginal endometriosis is mandatory in case of symp…
Deep endometriosis (DE) is considered to be one of the most challenging conditions to manage, especially when it invades surrounding organs like the rectum. Surgical excision of deep rectovaginal endometriosis is required when lesions are s…
ObjectiveTo compare the efficacy of a selective progesterone receptor modulator, ulipristal acetate, and a gonadotropin-releasing hormone antagonist, linzagolix, in a case of severe uterine adenomyosis.DesignCase report.SettingPrivate clini…
ObjectiveTo generate guidance for detailed uterine niche evaluation by ultrasonography in the non-pregnant woman, using a modified Delphi procedure amongst European experts.MethodsTwenty gynecological experts were approached through their m…
Like endometriosis, uterine adenomyosis is another enigmatic disease and remains a source of controversy. Uterine adenomyosis is characterized by the presence of endometrial glands in the myometrium. Two main theories may explain its pathog…
ObjectiveTo study the mechanisms of invasion and innervation of deep endometriosis in women.DesignMorphologic and immunohistochemical analysis of human endometriotic lesions.SettingAcademic research unit.Patient(s)Seventeen biopsy samples o…
Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and severity of symptoms, its pathogenesis and etiology have not yet b…
Deep endometriosis (DE) remains the most difficult endometriotic entity to treat. Medical treatment for DE can reduce symptoms but does not cure the disease, and surgical removal of the lesion is required when lesions are symptomatic, impai…
OBJECTIVE: To evaluate gynecological and obstetrical outcomes, as well as remaining myometrial thickness, after laparoscopic repair of a cesarean scar. DESIGN: Observational study and prospective evaluation of the remaining myometrium befo…
ObjectiveTo evaluate deep nodular endometriotic lesions induced in baboons over 12 months and analyze collective cell migration and nerve fiber density.DesignMorphologic and immunohistochemical analysis of endometriotic lesions induced in b…
Endometriosis remains a very enigmatic and perplexing disease. The exact mechanism by which endometriosis causes infertility is still unclear. In the present paper, we will review possible mechanisms leading to subfertility or infertility i…
Endometriosis is a disorder associated with a general inflammatory response in the peritoneal cavity. Oxidative stress is a potential factor involved in the pathophysiology of this disease, and reactive oxygen species (ROS) are implicated i…
ObjectiveTo determine the implications of collective cell migration in the invasion phenomenon observed in deep endometriotic lesions induced in a baboon model.DesignStudy of morphology and collective cell migration markers in invasive and …
ObjectiveTo evaluate the effects of endometriomas on the regulation of early follicular development.DesignHistologic analysis of prospectively collected biopsy samples.SettingResearch unit in a university hospital.Patient(s)Women <40 years …
ObjectiveTo study the occurrence of nerve fibers in deep nodular endometriotic lesions after nodules were induced in baboons and nerve fiber densities measured 6 months after the grafting procedure.DesignExperimental animal study.SettingAca…