Donnez O

No ORCID on file · 40 papers in corpus · active 2006-2025

Study types

  • article 16
  • review 10
  • other 7
  • letter 2
  • rct 2

Condition tags

  • endometriosis 27
  • infertility 7
  • chronic_pelvic_pain 6
  • adenomyosis 6
  • dyspareunia 4
  • endometrioma 3
  • dysmenorrhea 2
  • bowel_endometriosis 1
other 2025
Fertility and sterility ·doi:10.1016/j.fertnstert.2025.03.007
rct 2025
Acta obstetricia et gynecologica Scandinavica ·doi:10.1111/aogs.70005

INTRODUCTION: A symptomatic uterine niche is a long-term complication after a cesarean section (CS). A group of international niche experts reached consensus on a standardized definition of a disorder caused by a symptomatic niche, named ce…

rct 2024
Human Reproduction ·doi:10.1093/humrep/deae076

STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone ac…

2024
Facts, views & vision in ObGyn ·doi:10.52054/fvvo.16.3.036

BackgroundUterine niches in the Caesarean section scar are seen in approximately half of women with a history of caesarean delivery. Whilst a structured ultrasound assessment of caesarean defects has been described, there is no consensus on…

review 2023
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2023.102398

Cesarean scar disorder (CSD) is an entity recently defined as uterine niche with at least one primary or 2 secondary symptoms. CSDs can be visualized by hysterosalpingography, transvaginal sonography, saline infusion sonohysterography, hyst…

other 2023
JAMA network open ·doi:10.1001/jamanetworkopen.2023.5321

IMPORTANCE: Approximately 60% of women develop a uterine niche after a cesarean delivery (CD). A niche is associated with various gynecological symptoms including abnormal uterine bleeding, pain, and infertility, but there is little consens…

letter 2023
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.07.012
other 2022
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2021.09.019

RESEARCH QUESTION: Does a once-daily regimen of linzagolix, a new oral gonadotrophin-releasing hormone (GnRH) antagonist, given at a fully suppressive dose (200 mg) for 12 weeks, followed by a partially suppressive dose (100 mg) for a furth…

review 2021
Journal of clinical medicine ·doi:10.3390/jcm10215183

Deep endometriosis infiltrating the rectum remains a challenging situation to manage, and it is even more important when ureters and pelvic nerves are also infiltrated. Removal of deep rectovaginal endometriosis is mandatory in case of symp…

letter 2021
Fertility and sterility ·doi:10.1016/j.fertnstert.2021.01.038
review 2020
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2020.05.006

Deep endometriosis (DE) is considered to be one of the most challenging conditions to manage, especially when it invades surrounding organs like the rectum. Surgical excision of deep rectovaginal endometriosis is required when lesions are s…

article 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.04.017

ObjectiveTo compare the efficacy of a selective progesterone receptor modulator, ulipristal acetate, and a gonadotropin-releasing hormone antagonist, linzagolix, in a case of severe uterine adenomyosis.DesignCase report.SettingPrivate clini…

2019
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology ·doi:10.1002/uog.19049

ObjectiveTo generate guidance for detailed uterine niche evaluation by ultrasonography in the non-pregnant woman, using a modified Delphi procedure amongst European experts.MethodsTwenty gynecological experts were approached through their m…

article 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.01.035

Like endometriosis, uterine adenomyosis is another enigmatic disease and remains a source of controversy. Uterine adenomyosis is characterized by the presence of endometrial glands in the myometrium. Two main theories may explain its pathog…

article 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.08.016

ObjectiveTo study the mechanisms of invasion and innervation of deep endometriosis in women.DesignMorphologic and immunohistochemical analysis of human endometriotic lesions.SettingAcademic research unit.Patient(s)Seventeen biopsy samples o…

editorial 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.10.003
review 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.12.030

Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and severity of symptoms, its pathogenesis and etiology have not yet b…

review 2017
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.09.006

Deep endometriosis (DE) remains the most difficult endometriotic entity to treat. Medical treatment for DE can reduce symptoms but does not cure the disease, and surgical removal of the lesion is required when lesions are symptomatic, impai…

other 2017
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.09.033

OBJECTIVE: To evaluate gynecological and obstetrical outcomes, as well as remaining myometrial thickness, after laparoscopic repair of a cesarean scar. DESIGN: Observational study and prospective evaluation of the remaining myometrium befo…

article 2017
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.01.005

ObjectiveTo evaluate deep nodular endometriotic lesions induced in baboons over 12 months and analyze collective cell migration and nerve fiber density.DesignMorphologic and immunohistochemical analysis of endometriotic lesions induced in b…

review 2016
Panminerva medica

Endometriosis remains a very enigmatic and perplexing disease. The exact mechanism by which endometriosis causes infertility is still unclear. In the present paper, we will review possible mechanisms leading to subfertility or infertility i…

review 2016
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.07.1075

Endometriosis is a disorder associated with a general inflammatory response in the peritoneal cavity. Oxidative stress is a potential factor involved in the pathophysiology of this disease, and reactive oxygen species (ROS) are implicated i…

article 2015
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.05.011

ObjectiveTo determine the implications of collective cell migration in the invasion phenomenon observed in deep endometriotic lesions induced in a baboon model.DesignStudy of morphology and collective cell migration markers in invasive and …

article 2014
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.12.049

ObjectiveTo evaluate the effects of endometriomas on the regulation of early follicular development.DesignHistologic analysis of prospectively collected biopsy samples.SettingResearch unit in a university hospital.Patient(s)Women <40 years …

article 2013
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.06.014

ObjectiveTo study the occurrence of nerve fibers in deep nodular endometriotic lesions after nodules were induced in baboons and nerve fiber densities measured 6 months after the grafting procedure.DesignExperimental animal study.SettingAca…