Anne Marie Z Jukic

CONTEXT: Low vitamin D levels have been associated with female infertility, but the underlying mechanisms are not understood. OBJECTIVES: To examine vitamin D treatment, in vitro and in vivo, on human endometrial stromal cell (eSC) decidua…

BACKGROUND: While there is evidence that vitamin D deficiency is associated with long menstrual cycles, delayed ovulation, and reduced fertility, it is yet unknown if increasing vitamin D levels can regulate menstrual cycles, and thus possi…

INTRODUCTION: Inflammation is a marker of immune activation. Inflammation may have an effect on both ovarian function and luteal function, both essential to pregnancy. High inflammation may also signal dysregulated processes within the ovar…

BACKGROUND: Using menstrual products is a part of managing menstrual bleeding. Product use may represent individual, social, and economic influences. A few studies on menstrual product use from specific regions in the United States reported…

Study questionCan algorithms using wrist temperature, available on compatible models of iPhone and Apple Watch, retrospectively estimate the day of ovulation and predict the next menses start day?Summary answerAlgorithms using wrist tempera…

Some medical professional organizations have advocated for including the menstrual cycle as a vital sign in adolescence, but not in adulthood. However, documenting menstrual cycle patterns is not routine clinical or research practice. Vital…

BACKGROUND: Use of menstrual tracking data to understand abnormal bleeding patterns has been limited because of lack of incorporation of key demographic and health characteristics and confirmation of menstrual tracking accuracy. OBJECTIVE:…

ObjectiveTo determine the association between ovarian reserve biomarkers and future fertility among late reproductive-age women.DesignCohort study of participants enrolled in Time to Conceive (TTC), a time-to-pregnancy cohort study of the o…

BackgroundExtracellular vesicles (EVs), membrane-bound particles containing a variety of RNA types, DNA, proteins, and other macromolecules, are now appreciated as an important means of communication between cells and tissues, both in norma…

BackgroundLocal inflammation plays an important role in normal folliculogenesis and ovulation, and conditions of chronic systemic inflammation, such as obesity and polycystic ovarian syndrome, can disrupt normal follicular dynamics.Objectiv…

BackgroundProspective longitudinal cohorts assessing women's health and gynecologic conditions have historically been limited.ObjectiveThe Apple Women's Health Study was designed to gain a deeper understanding of the relationship among mens…

BackgroundMobile applications (apps) present a new opportunity to study menstrual cycles and time to pregnancy. Understanding the characteristics of cycle tracking app users is important to evaluate the feasibility of recruiting participant…

BackgroundInflammation may contribute to subfertility but this has not been well-explored in large prospective cohort studies.MethodsWe conducted a prospective 12-month cohort study of time to pregnancy in North Carolina, the Time to Concei…

Study questionIs preconception vitamin D level associated with the risk of miscarriage?Summary answerPreconception vitamin D levels are not associated with the risk of miscarriage in a population of women conceiving naturally.What is known …

BackgroundThe role of vitamin D in reproductive health is still unclear. This study aimed to assess the effect of serum 25-hydroxyvitamin D (25(OH)D), among preconception couples, on fecundity, and the associations between 25(OH)D concentra…

ContextWhile age-related changes in menstrual cycle length are well known, it is unclear whether anti-Müllerian (AMH) or other ovarian reserve biomarkers have a direct association with cycle length.ObjectiveTo determine the association betw…

Purpose of reviewThe goal of this review was to evaluate whether the fields available in iOS mobile phone apps for recording menstrual cycle symptoms are able to be harmonized across platforms for potential use in research, such as aggregat…

BackgroundStudies investigating the effects of pain-relieving medication use on conceiving a pregnancy have shown conflicting results. Furthermore, no previous study has examined medication use around ovulation or implantation and the assoc…

Study questionIs pre-conception 25(OH)D associated with the per cycle probability of conception, i.e fecundability, in a prospective cohort study?Summary answerThere are suggestive associations of high 25(OH)D (at least 50 ng/ml) with incre…

ObjectiveThe aim of the study was to examine the associations between 25-hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve in a large community-based sample of women.MethodsIn 2010 to 2016, women aged 30 to 44 years without any k…

BackgroundVitamin D insufficiency is associated with subfertility and prolonged estrus cycles in animals, but humans have not been well studied.MethodsA prospective time-to-pregnancy study, Time to Conceive (2010-2015), collected up to 4 mo…

ObjectiveTo determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies.DesignProspective cohort study.SettingNot applicable.Patient(s)Women (n = 533), b…

OBJECTIVE: To provide female age-related estimates of fecundity and incidence of infertility by history of prior pregnancy among women 30-44 years of age. DESIGN: Prospective, time-to-pregnancy cohort study. SETTING: Not applicable. PATI…

OBJECTIVE: Vitamin D has been linked to antimüllerian hormone levels, suggesting a possible association with greater ovarian reserve, but large population-based studies are lacking. Our objective was to explore the association between vitam…

BACKGROUND Late implantation and the pattern of early rise in hCG have been associated with early pregnancy loss. We explored factors that might be predictive of these markers of poor embryonic health in spontaneously conceived pregnancies.…