Chandler RL

No ORCID on file · 8 papers in corpus · active 2015-2022

Study types

  • other 3
  • article 1

Condition tags

  • endometriosis 3
  • infertility 1
  • adenomyosis 1
other 2022
Endometrial Epithelial ARID1A Is Required for Uterine Immune Homeostasis during Early Pregnancy
International journal of molecular sciences ·doi:10.3390/ijms23116067

A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich interaction domain 1A (ARID1A) must be properly expressed to main…

2022
Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-01030-0

Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are highly regulative of neighborin…

2022
SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression.
Cells ·doi:10.3390/cells11061000

Endometrial cancer (EC) is characterized by high estrogen levels unopposed by progesterone. Treatment with progestins is standard for early EC, but the response to progestins is dependent on progesterone receptor (PGR) expression. Here, we …

other 2020
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
Cell reports ·doi:10.1016/j.celrep.2020.108366

Endometriosis affects 1 in 10 women and is characterized by the presence of abnormal endometrium at ectopic sites. ARID1A mutations are observed in deeply invasive forms of the disease, often correlating with malignancy. To identify epigene…

other 2020
SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity
Human molecular genetics ·doi:10.1093/hmg/ddaa227

Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related g…

article 2019
A mouse model of endometriosis mimicking the natural spread of invasive endometrium
Human Reproduction ·doi:10.1093/humrep/dez253

STUDY QUESTION: Is it possible to establish a genetically engineered mouse model (GEMM) of endometriosis that mimics the natural spread of invasive endometrium? SUMMARY ANSWER: Endometriosis occurs in an ARID1A (AT-rich interactive domain-c…

2019
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Nature communications ·doi:10.1038/s41467-019-11403-6

ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when comb…

2015
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Nature communications ·doi:10.1038/ncomms7118

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is not sufficient for tumour formation, but requires…