Jeanne Holladay

ORCID: 0000-0002-6081-7413 · 4 papers in corpus
other 2020
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
Cell reports ·doi:10.1016/j.celrep.2020.108366

Endometriosis affects 1 in 10 women and is characterized by the presence of abnormal endometrium at ectopic sites. ARID1A mutations are observed in deeply invasive forms of the disease, often correlating with malignancy. To identify epigene…

other 2020
SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity
Human molecular genetics ·doi:10.1093/hmg/ddaa227

Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related g…

article 2019
A mouse model of endometriosis mimicking the natural spread of invasive endometrium
Human Reproduction ·doi:10.1093/humrep/dez253

STUDY QUESTION: Is it possible to establish a genetically engineered mouse model (GEMM) of endometriosis that mimics the natural spread of invasive endometrium? SUMMARY ANSWER: Endometriosis occurs in an ARID1A (AT-rich interactive domain-c…

2019
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Nature communications ·doi:10.1038/s41467-019-11403-6

ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when comb…