Leach RE

No ORCID on file · 12 papers in corpus · active 1990-2021

Study types

  • other 4
  • article 2

Condition tags

  • endometriosis 5
  • infertility 2
  • adenomyosis 1
other 2021
FSH dose is negatively correlated with number of oocytes retrieved: analysis of a data set with ~650,000 ART cycles that previously identified an inverse relationship between FSH dose and live birth rate
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-021-02179-0

PURPOSE: To evaluate whether total FSH dose was negatively correlated with number of oocytes retrieved in a large data set where previously, a negative correlation between FSH dose and live birth rate was identified. METHODS: Data from 650…

other 2020
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
Cell reports ·doi:10.1016/j.celrep.2020.108366

Endometriosis affects 1 in 10 women and is characterized by the presence of abnormal endometrium at ectopic sites. ARID1A mutations are observed in deeply invasive forms of the disease, often correlating with malignancy. To identify epigene…

2019
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Nature communications ·doi:10.1038/s41467-019-11403-6

ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when comb…

article 2019
Loss of HDAC3 results in nonreceptive endometrium and female infertility
Science translational medicine ·doi:10.1126/scitranslmed.aaf7533

genes in humans. Our results suggest that HDAC3 is critical for endometrial receptivity and decidualization.

2016
Assisted reproductive technology use and outcomes among women with a history of cancer.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dev288

Study questionHow do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to women without cancer?Summary answerThe likelihood of a live birth after ART among women with prior cancer…

2016
Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dew080

Study questionDoes a single intrauterine infusion of human chorionic gonadotropin (hCG) at the time corresponding to a Day 3 embryo transfer in oocyte donors induce favorable molecular changes in the endometrium for embryo implantation?Summ…

other 2015
ARID1A Is Essential for Endometrial Function during Early Pregnancy
PLoS genetics ·doi:10.1371/journal.pgen.1005537

AT-rich interactive domain 1A gene (ARID1A) loss is a frequent event in endometriosis-associated ovarian carcinomas. Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus, and 50% of women…

2015
Cancer in women after assisted reproductive technology.
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.07.1135

ObjectiveTo evaluate the risk of cancer after assisted reproductive technology (ART) therapy.DesignLongitudinal cohort study.SettingNot applicable.Patient(s)New York, Texas, and Illinois residents between 2004 and 2009, treated with ART, co…

article 2013
β ‐Catenin activation contributes to the pathogenesis of adenomyosis through epithelial–mesenchymal transition
The Journal of Pathology ·doi:10.1002/path.4224

Adenomyosis is defined by the presence of endometrial glands and stroma within the myometrium. Despite its frequent occurrence, the precise aetiology and physiopathology of adenomyosis is still unknown. WNT/β-catenin signalling molecules ar…

2012
Cumulative birth rates with linked assisted reproductive technology cycles.
The New England journal of medicine ·doi:10.1056/nejmoa1110238

BackgroundLive-birth rates after treatment with assisted reproductive technology have traditionally been reported on a per-cycle basis. For women receiving continued treatment, cumulative success rates are a more important measure.MethodsWe…

2012
High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/der436

BackgroundAlthough histological dating of endometrial biopsies provides little help for prediction or diagnosis of infertility, analysis of individual endometrial proteins, proteomic profiling and transcriptome analysis have suggested sever…

other 1990
Absence of antisperm antibodies and factors influencing sperm motility in the cul-de-sac fluid of women with endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(16)53294-4

No detrimental effect on sperm motility characteristics by PF from women with low-stage endometriosis was documented when incubated for 3 to 6 hours. Although 1 of 31 women with endometriosis possessed IgA and IgG to sperm in her PF, its si…