S. K. Smith

Endometriosis is characterized by an increase in the number, activation and secretory activity of peritoneal fluid macrophages. Factors regulating the activation of these cells may be important in the pathophysiology of this disease. In thi…

Endometriosis, a debilitating disease associated with infertility, is characterized by the prolonged presence of ectopic endometrial tissue and the involvement of activated peritoneal fluid macrophages. Apoptosis, which occurs in both endom…

Abstracts of the 13th Annual Meeting of the ESHRE, Edinburgh 1997 significantly increased (P < 0.05) in Norplant-treated endometrium following RU486 administration.Conclusion: Endometrium exposed to Norplant® and antiprogestogen displayed a…

Abstract Menorrhagia is the subjective complaint of heavy periods. Its cause in the vast majority of cases is unknown. As one of the commonest referrals for gynaecological consultation (Bradlow et al. 1992) this statement may appear surpris…

Angiogenesis is important in the pathophysiology of endometriosis, a condition characterized by implantation of ectopic endometrium in the peritoneal cavity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved i…

Active endometriosis is characterized by hypervascularization both within and surrounding the implant; therefore the presence of angiogenic factors in the peritoneal environment would be of great importance. Vascular endothelial growth fact…

Reproductive Molecular Research Group, Department of Obstetrics and Gynaecology, University of Cambridge, Clinical School, The Rosie Maternity Hospital, Cambridge, United Kingdom. Hum Reprod 1996;11:220-223

(1995). Gynaecological case reports: Successful medical treatment of sub-diaphragmatic endometriosis. Journal of Obstetrics and Gynaecology: Vol. 15, No. 3, pp. 206-206.

Journal Article The aetiology of endometriosis Get access S.K. Smith S.K. Smith Department of Obstetrics and Gynaecology, The Rosie Maternity HospitalRobinson Way, Cambridge CB2 2SW, UK Search for other works by this author on: Oxford Acade…

Growth factors play a role in the cyclical growth and vascularization of normal endometrium. Abnormal endometrial proliferation and neovascularization may result in endometriosis. This study determines the presence and localization of acidi…

OBJECTIVE: The duration of action of a gonadotrophin releasing hormone (GnRH) agonist implant designed to be effective for 3 months was investigated in women by monitoring drug release and ovarian hormone secretion. Serum inhibin secretion …

Endometrial proliferation is stimulated by oestradiol. The precise mechanism is poorly understood, but may be mediated by epidermal growth factor (EGF). The aim of the present study was to assess the effects of oestradiol and EGF on glandul…

Ten endometriosis patients received luteinizing hormone releasing hormone (LH-RH) agonist (buserelin) implant injections (6.6 mg subcutaneously) at days 0, 42, 84 and 126. Serum LH and follicle-stimulating hormone (FSH) were lowered by day …

Thirty-one patients with endometriosis were typed for HLA-A, B and DR antigens. No association was found between the disease and any DR specificity, which may be taken as evidence against an autoimmune aetiology.

The action of progesterone and glucocorticoids on human proliferative phase endometrium has been investigated using isolated fragments of endometrium cultured for 2 to 3 days. The action of progesterone (200-500 nM) in this system is to red…

The endogenous concentrations of prostaglandins F2 alpha (PGF 2 alpha) and E (PGE) were measured during the luteal phase of the menstrual cycle in the endometrium from 14 women with unexplained menorrhagia (measured menstrual blood loss in …

Concentrations of prostaglandin F2 alpha (PGF2 alpha) and prostaglandin E (PGE) were measured in endometrium from 18 women with ectopic pregnancies. In the nine pregnancies not associated with vaginal bleeding or an intra-uterine contracept…