P-128. Regulation of vascular endothelial growth factor expression in human endometrium by steroids: in-vitro and in-vivo studies

Abstracts of the 13th Annual Meeting of the ESHRE, Edinburgh 1997 significantly increased (P < 0.05) in Norplant-treated endometrium following RU486 administration.Conclusion: Endometrium exposed to Norplant® and antiprogestogen displayed a significant increase in glandular ER concentration and all biopsies showed proliferative histology, consistent with endometrial regeneration.The regular (probably monthly) administration of an anti-progesterone may improve bleeding patterns among Norplant users.Because it induces ovulation, the contraceptive efficacy of Norplant may be reduced but a larger scale efficacy study is required.