Shen Y

PURPOSE: To investigate the association between dendritic cell maturation deficits and pain in patients with adenomyosis and explore potential neuro-immune mechanisms. METHODS: Uterine tissues from 24 patients with adenomyosis (AM) and 15 …

Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI) as well as the invasiveness and recurrence risks associated with laparoscopy. To overcome these challenges, we devel…

BACKGROUND: Sexual health plays a crucial role in the overall health and quality of life of adults. Currently, various Patient-Reported Outcome Measures (PROMs) exist globally to assess sexual health from different dimensions. However, the …

ObjectivesThis study aimed to develop a multimodal predictive model that integrates clinical data, radiomics, and three-dimensional deep learning to forecast acute respiratory distress syndrome in patients with acute pancreatitis.MethodsThi…

Endometriosis (EMs) is a gynecological inflammatory disease that depends on estrogen. Its chief symptoms include dysmenorrhea, chronic pelvic pain, reduced fertility, and pelvic masses. Although various hormonal therapies and surgical treat…

STUDY OBJECTIVE: To develop and validate a non-invasive, blood-based diagnostic assay for endometriosis that performs accurately across menstrual cycle phases and complements existing imaging modalities. DESIGN: Multicenter case-control st…

PurposeAccurate prognostic prediction remains a significant challenge in the management of low-grade serous ovarian cancer (LGSOC), a rare and molecularly distinct histologic subtype. This study aimed to develop a prediction model visualize…

OBJECTIVE: The aim of the present retrospective cohort study was to compare the clinical characteristics, perioperative outcomes and pregnancy outcomes of laparo-endoscopic single-site (LESS) surgery, conventional laparoscopy (CL) surgery a…

BackgroundMatrix remodeling-associated 7 (MXRA7) plays a key role in physiological and pathological processes involving the extracellular matrix (ECM) and tissue remodeling. Recent studies have highlighted its functions in tissue injury, im…

BackgroundThe clinical prognostic factors for ovarian clear cell carcinoma (OCCC) are limited, and we aim to construct a model to predict the survival of OCCC patients.MethodsData were extracted from the SEER database for patients diagnosed…

Liver fibrosis is induced by persistent stimulation of various factors, resulting from complex multicellular interactions and multifactorial networks. Without intervention, it can progress to cirrhosis and even liver cancer. Current underst…

In addition to chromosomal abnormalities, excessive systemic or local inflammation, particularly in the uterus, may also contribute to the pathogenesis of early pregnancy loss. Recently, several systemic immune inflammation indices, includi…

OBJECTIVE: The endometrial microbiota exerts a crucial role in maintaining the health of the female reproductive system. As such, in this study, we have examined the composition of the microbiota in endometrium tissues with and without endo…

Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some common botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial biological activities. In this paper, we sys…

MOTIVATION: Normalization is a critical step in quantitative PCR (qPCR) and droplet digital PCR (ddPCR) experiments to ensure accurate and reproducible gene expression analysis. However, commonly used endogenous controls such as miR-16 for …

BackgroundSurgery is the primary treatment for Endometrial Stromal Sarcoma (ESS), however, a substantial proportion of patients with ESS experience recurrence or metastasis. Currently, surgery and local ablation are the main treatments for …

IntroductionAlthough advanced paternal age (APA) is increasingly scrutinized in reproductive medicine, its independent impact on embryo development and clinical outcomes remains contentious, particularly when controlling for maternal age an…

INTRODUCTION: Dynamic changes in adenomyotic lesions in animal models have been difficult to observe and evaluate in vivo on a regular basis. Therefore, this study aims to investigate the feasibility of establishing a rat model of adenomyos…

IntroductionAnimal reproduction is a highly complex process influenced by numerous factors, and previous study has suggested that Hungatella hathewayi (HH) may have potential benefits for swine reproduction. Building on these findings, the …

RNF144 family proteins, including RNF144A and RNF144B, members of the RING-between-RING domain-containing ubiquitin E3 ligase family, serve as critical regulators of protein ubiquitination. Despite increasing research attention in recent ye…

BackgroundBronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in preterm infants, and its incidence has gradually increased with advances in medical technology. BPD is associated with multiple complications, significant…

Simulation approach involves the use of computers and mathematical models to simulate real systems for experimentation or tests that evaluate the behavior and performance of a system or predict the results of various hypothetical scenarios.…

Endometriosis is a prevalent chronic gynecological disease that poses significant challenges for treatment due to its extensive lesions, diverse morphology, unknown etiology, and tendency for recurrence. In the early 21st century, the stem …

Endometriosis is characterized by aberrant epigenetic regulation, and our study reveals that both Ubiquitin Specific Protease 7 (USP7) and DNA methyltransferase 1 (DNMT1) are significantly overexpressed in endometriosis tissues. Functional …