While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F…
BACKGROUND: Endometriosis (EMS) is a common chronic gynecological disorder that increases the risk of ovarian cancer by approximately threefold. However, the molecular mechanisms underlying this association remain unclear. METHODS: Mendeli…
Tumor microenvironment is well known to have a key role in tumor development. Extracellular vesicles are capable in cell signaling transduction and important in regulation of tumor microenvironment. To investigate whether peritoneal fluid–d…
BACKGROUND: Endometriosis and breast cancer are significant global health burdens affecting women worldwide. Both conditions share notable characteristics including estrogen dependence, progressive growth patterns, recurrence tendencies, an…
Human endogenous retroviruses (HERVs) have evolved from exogenous retroviruses and account for approximately 8% of the human genome. A growing number of findings suggest that the abnormal expression of HERV genes is associated with schizoph…
BACKGROUND: As ovarian clear cell carcinoma (OCCC) has distinct clinical features, biology, genetic characteristics and mechanisms of pathogenesis, and whether the origin of endometriosis or not affects the prognosis of OCCC remains controv…