Discover oncology

We report a rare case of sporadic cervical clear cell adenocarcinoma (CCAC) in a 46-year-old perimenopausal woman without the classic risk factors of in utero diethylstilbestrol (DES) exposure or high-risk human papillomavirus (HPV) infecti…

Gynecological cancers, such as vulvar, cervical, endometrial, and ovarian cancers, are the leading causes of morbidity and mortality among women globally. Conventional management modalities like chemotherapy, surgery, and radiotherapy have …

Ovarian cancer (OC) remains a malignancy characterized by obscure risk factors and unfavorable prognosis. While 3-tert-butyl-4-hydroxyanisole (3-BHA) is suspected of exerting toxic effects on ovarian health, the precise molecular mechanisms…

Ovarian cancer ranks sixth as the most common cancer and fifth as the most deadly malignancy among women worldwide. In addition, it places third among the most common gynecological cancers. Which proves that it is a significant medical prob…

Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy, with prognosis limited by extensive resistance to platinum-based therapy. Although the pregnane X receptor (PXR) has been implicated in chemoresistance, the u…

Endometrioid carcinoma is one of the most prevalent malignant neoplasms in gynecology, in contrast to perivascular epithelioid cell tumor (PEComa), a rare stromal tumor, which is seldom encountered in the female genital system. The coexiste…

While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F…

BackgroundMatrix remodeling-associated 7 (MXRA7) plays a key role in physiological and pathological processes involving the extracellular matrix (ECM) and tissue remodeling. Recent studies have highlighted its functions in tissue injury, im…

BACKGROUND: Endometriosis (EMS) is a common chronic gynecological disorder that increases the risk of ovarian cancer by approximately threefold. However, the molecular mechanisms underlying this association remain unclear. METHODS: Mendelia…

BackgroundIschemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subty…

ObjectiveThe aim of this study was to comparatively analyze the therapeutic effects of uterine artery embolization (UAE) and laparoscopic myomectomy (LM) on uterine fibroids to determine which treatment method is more beneficial for patient…

BackgroundThe clinical prognostic factors for ovarian clear cell carcinoma (OCCC) are limited, and we aim to construct a model to predict the survival of OCCC patients.MethodsData were extracted from the SEER database for patients diagnosed…

Endometrial cancer (EC) is the most prevalent gynecological malignancy in developed countries, with incidence rates steadily increasing due to factors such as obesity, aging populations, and changes in reproductive behavior. While mortality…

Epithelial ovarian cancer (EOC) poses considerable challenges in selecting appropriate treatments due to the interplay of factors such as drug efficacy, safety, cost, resistance, and patient compliance. To address these complexities, this s…

Gastric cancer (GC) is one of the most common malignancies and is a highly heterogeneous disease; it is also a leading cause of cancer-related death. Owing to the complexity and late-stage diagnosis of GC, the prognosis remains poor. To exp…

BackgroundNei Like DNA Glycosylase 2 (NEIL2) is strongly associated with the risk of Cervical cancer (CC), but the mechanism is not yet clear. Therefore, the aim of this study was to explore the potential mechanisms of NEIL2 as a novel prog…

BackgroundBreast cancer (BC) continues to be a predominant cause of cancer-related deaths among women globally, highlighting the complexity of the disease, its propensity for metastasis, and resistance to conventional therapies. The discove…

BackgroundOvarian clear cell cancer (OCCC) is a pathological type of ovarian cancer. OCCC responds poorly to platinum-based chemotherapy drugs and immunotherapy. Currently, there is a lack of targeted drugs for OCCC. It is very urgent to fi…

Ovarian cancer has a high mortality rate, primarily due to late diagnosis and complex pathogenesis. This study develops an integrative prognostic model combining genetic, clinical, and immunological data to predict outcomes in ovarian cance…

BackgroundLncRNA LINC02381 has emerged as a promising tumor biomarker; however, its involvement in the pathogenesis of pancreatic cancer remains unexplored at this time. The objective of this study is to elucidate the regulatory effect of L…

ObjectiveOvarian cancer (OC) is a common malignant tumor in women, with poor prognosis and high mortality rates. Early diagnosis, screening, and prognostic prediction of OC have long been focal points and challenges in this field. In recent…

BackgroundMicroRNAs (miRNAs) exert a crucial role in the progression of lung cancer (LC) and can serve as prognostic biomarkers.AimTo analyze the prognostic value of miR-3613-5p and its regulatory effect on XPO6 in LC, this study was conduc…

Ovarian cancer (OC), a common gynecological malignancy, seriously threatens the lives and health of women. Though several serological markers are used for the early diagnosis of OC, most have low specificity and sensitivity. Micro-RNAs (miR…

Across the globe, breast cancer remains the most common malignancy in women. Although novel therapies introduced during the last years have helped reducing its mortality, nevertheless it remains a major public health problem associated with…

BackgroundEndometrial cancer represents a significant health challenge, with rising incidence and complex prognostic challenges. This study aimed to develop a robust predictive model integrating programmed cell death-related genes and advan…