Andrew W. Horne

This survey study examines which dietary modifications or supplements were perceived as beneficial for pain management by individuals with endometriosis.

BACKGROUND: Innate lymphoid cells (ILCs) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-most common ILC subset in the uterine mucosa, but their role remains unclear. METHODS: Here w…

INTRODUCTION: Endometriosis is a common, benign, chronic inflammatory disease with multiple consequences, from chronic pain to systemic comorbidities and poor quality of life. As it usually affects people of reproductive age, one of the mos…

IMPORTANCE: Endometriosis is a chronic, estrogen-dependent, inflammatory disease defined by endometrial-like tissue (lesions) outside the uterine lining. It affects up to 10% of women worldwide, and 9 million women in the US, during reprodu…

Endometriosis is a chronic neuroinflammatory disorder believed to impact on the wellbeing of more than 190 million women and people assigned female at birth. The defining hallmark of endometriosis is the growth of endometrial-like tissue as…

STUDY QUESTION: How does pre-diagnosis use of hospital care differentiate between women later diagnosed with endometriosis and age-matched controls without a diagnosis? SUMMARY ANSWER: Women with hospital-diagnosed endometriosis had more f…

BACKGROUND: Conditioned pain modulation (CPM) is considered a human proxy for descending inhibitory pain pathways. However, there is wide variation in the CPM response described in the literature and ongoing debate about its utility. METHO…

Endometriosis is a common, chronic condition associated with debilitating pain, fatigue, and heterogeneous symptom presentation. In this exploratory study, 68 participants with confirmed endometriosis were monitored for up to three 4-6-week…

Abstract Study question What is the population prevalence of endometriosis in those with infertility (and vice-versa) and likelihood of pregnancy in women with endometriosis with and without infertility? Summary answer Women with endometrio…

ABSTRACT: Current endometriosis treatments primarily focus on pain management, despite many patients also experiencing fatigue, which significantly impacts their quality of life. This study aimed to evaluate the perceived effectiveness of e…

OBJECTIVE: To develop and validate models to predict which endometriosis patients are likely to experience pain reduction following therapeutic laparoscopy using intraoperative findings and patient characteristics. DESIGN: A retrospective …

INTRODUCTION: Endometriosis is characterized by a range of non-specific symptoms which may contribute to the significant delay in diagnosis. Knowledge about the distribution of endometriosis symptoms across different geographical regions as…

OBJECTIVE: To describe sociodemographic characteristics of women with hospital diagnosed endometriosis in Denmark and compare them with women without endometriosis. STUDY DESIGN: Case-control study using Danish national registers. Cases we…

Abstract Endometriosis is a chronic, hormone-dependent condition that affects 190 million women worldwide. There are no validated biomarkers for endometriosis and this delays diagnosis and treatment. We performed serum steroid metabolome pr…

Endometriosis is a common and debilitating neuro-inflammatory disorder that is associated with chronic pain. Definitive diagnosis is based on the presence of endometrial-like tissue (lesions) in sites outside the uterus. Kynurenine monooxyg…

INTRODUCTION: Chronic pelvic pain affects up to 24% of women worldwide and for up to 55% of these there is no associated pathology. Despite this there are no established treatments in this cohort. This is a secondary analysis of a randomise…

Innate lymphoid cells (ILC) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-most common ILC subset in the uterine mucosa, but their role remains unclear. Here we define two subsets of…

Endometriosis is a common, chronic, incurable condition the hallmark of which is the presence of lesions (tissue resembling endometrium) in sites outside the womb, with symptoms including chronic debilitating pain and fatigue. However, curr…

Endometriosis is a chronic disorder with debilitating symptoms that is difficult to diagnose and treat. Advances in imaging technologies and strategies for the management of symptoms are improving the quality of life of patients by reducing…

Endometriosis is a common disorder associated with pain, gastrointestinal and urinary symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions found predominantly in the pelvis. Mechanisms that contribut…