Todd L Edwards

No ORCID on file · 11 papers in corpus · active 2013-2026

Study types

  • other 4
  • meta-analysis 2
  • review 2
  • article 1
  • erratum 1

Condition tags

  • endometriosis 11
  • infertility 1
other 2026
Genetically-predicted placental gene expression links to uterine fibroids and endometriosis
Placenta ·doi:10.1016/j.placenta.2026.03.023

INTRODUCTION: Mother-to-child disease transmission begins in utero, with the placenta playing a critical role in pregnancy and offspring health. Uterine leiomyomata (fibroids, UFs) and endometriosis (ENDO) are common gynecologic diseases th…

other 2025
Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women
Research square ·doi:10.21203/rs.3.rs-8116602/v1

We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of the Global Biobank Meta-Analysis Initiative (GBMI). Ou…

meta-analysis 2023
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Nature genetics ·doi:10.1038/s41588-023-01323-z

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

erratum 2022
Author Correction: Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
Nature communications ·doi:10.1038/s41467-022-33222-y
review 2021
Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways
Human Reproduction ·doi:10.1093/humrep/deab254

STUDY QUESTION: Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships? SUMMARY ANSWER: Our results confirm a significant but non-causal associat…

article 2020
Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality
Human genetics ·doi:10.1007/s00439-020-02223-6
review 2019
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
Nature communications ·doi:10.1038/s41467-019-12536-4

Abstract Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 …

preprint 2018
Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis
·doi:10.1101/324905

Uterine leiomyomata (UL), also known as uterine fibroids, are the most common neoplasms of the reproductive tract and the primary cause for hysterectomy, leading to considerable impact on women’s lives as well as high economic burden 1,2 . …

other 2017
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry
Scientific reports ·doi:10.1038/s41598-017-10440-9

Genome-wide association (GWA) studies have identified 19 independent common risk loci for endometriosis. Most of the GWA variants are non-coding and the genes responsible for the association signals have not been identified. Herein, we aime…

meta-analysis 2017
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Nature communications ·doi:10.1038/ncomms15539

Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide ass…

other 2013
Phenotyping clinical disorders: lessons learned from pelvic organ prolapse
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2012.11.030

Genetic epidemiology, the study of genetic contributions to risk for disease, is an innovative area in medicine. Although research in this arena has advanced in other disciplines, few genetic epidemiological studies have been conducted in o…