Author Correction: Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

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This paper corrects a previous error in Table 1 regarding odds ratios for single-nucleotide polymorphisms associated with uterine leiomyomata.

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This author correction to a Nature Communications article updates an error in Table 1, in which the odds ratios in the overview of lead SNPs across 29 independent loci from an uterine leiomyomata (UL) GWAS meta-analysis were incorrectly calculated. The corrected table provides revised lead SNPs, risk allele frequencies in European samples, and odds ratios with 95% confidence intervals, and labels certain loci as previously associated with endometriosis or previously associated with UL. The paper’s correction specifically replaces the previous incorrect version in both the PDF and HTML. This paper is centrally about endometriosis — it reports genomic analyses showing shared genetic origins between uterine leiomyomata and endometriosis, with several UL loci explicitly marked as previously linked to endometriosis.

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Corrections & amendments Author Correction: Genome-wide association and epidemiologi- cal analyses reveal common genetic origins between uterine leiomyomata and endometriosis C. S. Gallagher, N. Mäkinen, H. R. Harris, N. Rahmioglu, O. Uimari ,J .P .C o o k , N .S h i g e s i ,T .F e r r e i r a ,D .R .V e l e z - E d w a r d s ,T .L .E d w a r d s,S .M o r t l o c k , Z. Ruhioglu ,F .D a y ,C .M .B e c k e r , V. Karhunen, H. Martikainen, M.- R. Järvelin ,R .M .C a n t o r ,P .M .R i d k e r ,K .L .T e r r y ,J .E .B u r i n g ,S .D .G o r d o n, S. E. Medland ,G .W .M o n t g o m e r y,D .R .N y h o l t ,D .A .H i n d s ,J .Y .T u n g , t h e2 3 a n d M eR e s e a r c hT e a m * ,J .R .B .P e r r y ,P .A .L i n d,J .N .P a i n t e r , N. G. Martin , A. P. Morris, D. I. Chasman, S. A. Missmer, K. T. Zondervan & C. C. Morton The original version of this Article contained an error in Table1,i nw h i c ht h eo d d sr a t i o sw e r e incorrectly calculated. The correct version of Table1 is: Table 1 | Overview of lead SNPs with significant associations at 29 independent loci in UL GWAS meta-analysis Locus Lead SNP RA OA RAF EUR PMeta OR (95% CI) Gene(s) of interest a 1p36.12b,c rs7412010 C G 0.15 2.4 × 10 −29 1.13 (1.11–1.16) WNT4, CDC42 2p23.2 rs55819434 A G 0.91 5.6 × 10 −09 0.92 (0.90–0.95) BABAM2 2p25.1b,c rs35417544 T C 0.69 2.3 × 10 −19 1.09 (1.07–1.10) GREB1 3q26.2c rs35446936 A G 0.24 1.0 × 10 −08 0.95 (0.93–0.96) TERC 4q12c rs62323682 T C 0.94 4.9 × 10 −18 0.87 (0.84–0.90) LNX1, PDGFRA 4q13.3c rs12640488 A G 0.52 4.0 × 10 −14 0.94 (0.92–0.96) SULT1B1 4q22.3 rs4699299 T C 0.69 4.7 × 10 −08 0.95 (0.94–0.97) PDLIM5 5p15.33c rs72709458 T C 0.23 4.7 × 10 −21 1.10 (1.08–1.13) TERT 5q35.2c rs2456181 C G 0.49 1.1 × 10 −11 0.94 (0.93–0.96) ZNF346, UIMC1 6p21.31 rs116251328 A T 0.02 3.0 × 10 −08 1.15 (1.09–1.21) GRM4, HMGA1 6q25.2b,c rs58415480 C G 0.84 1.9 × 10 −54 0.84 (0.82–0.86) SYNE1, ESR1 7q31.2 rs2270206 A C 0.16 4.6 × 10 −08 1.06 (1.04–1.09) WNT2 9p24.3c rs10976689 A G 0.60 2.4 × 10 −13 0.94 (0.93–0.96) ANKRD15 10q24.3c rs9419958 T C 0.13 1.1 × 10 −16 1.10 (1.08–1.13) OBFC1, SLK 10p11.22 rs10508765 A G 0.80 1.5 × 10 −10 1.07 (1.05–1.09) ZEB1, ARHGAP12 11p15.5c rs547025 T C 0.92 1.5 × 10 −14 1.13 (1.09–1.16) RIC8A, BET1L 11p14.1b rs11031006 A G 0.14 5.7 × 10 −15 0.91 (0.89–0.93) FSHB 11p13c rs61889186 C G 0.86 1.4 × 10 −25 0.89 (0.87–0.91) WT1 11p13c rs2785202 C G 0.55 6.9 × 10 −14 1.06 (1.05–1.08) PDHX, CD44 11q22.3c rs149934734 T C 0.03 1.1 × 10 −27 1.33 (1.26–1.40) C11orf65, KDELC2 12q13.11c rs2131371 A C 0.28 1.6 × 10 −18 0.93 (0.91–0.94) SLC38A2 12q15 rs11178393 T C 0.89 3.3 × 10 −08 1.08 (1.05–1.10) PTPRR 12q24.31 rs28583837 A G 0.22 2.3 × 10 −08 0.94 (0.92–0.96) PITPNM2 13q14.11c rs117245733 A G 0.02 5.7 × 10 −14 1.31 (1.21–1.39) FOXO1 17p13.1c rs78378222 T G 0.99 7.1 × 10 −31 0.65 (0.60–0.70) SHBG, TP53 20p12.3c rs16991615 A G 0.07 8.8 × 10 −10 1.11 (1.07–1.14) MCM8, TRMT6 22q13.1c rs4821939 A T 0.20 7.8 × 10 −16 1.08 (1.06–1.10) TNRC6B Xp26.2c rs12392108 A T 0.31 5.9 × 10 −46 1.13 (1.11–1.15) RAP2C Xq13.1c rs4360450 A G 0.37 2.1 × 10 −18 1.08 (1.06–1.10) MED12 SNP single-nucleotide polymorphism,RA risk allele, OA other allele, RAFEUR average risk allele frequency in European samples,OR odds ratio a≤300 kb distant from association signal bLoci previously associated with endometriosis cLoci previously associated with UL Correction to:Nature Communications https://doi.org/10.1038/s41467-019-12536-4, published online 24 October 2019 https://doi.org/10.1038/s41467-022-33222-y Check for updates nature communications (2022) 13:5543 | 1 1234567890():,; 1234567890():,; which replaces the previous incorrect version: This has been corrected in both the PDF and HTML versions of the Article. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visithttp://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2022 Table 1 | Overview of lead SNPs with significant associations at 29 independent loci in UL GWAS meta-analysis Locus Lead SNP RA OA RAF EUR PMeta OR (95% CI) Gene(s) of interest a 1p36.12b,c rs7412010 C G 0.15 2.4 × 10 −29 1.13 (1.11–1.16) WNT4, CDC42 2p23.2 rs55819434 A G 0.91 5.6 × 10 −09 1.09 (1.06–1.12) BABAM2 2p25.1b,c rs35417544 T C 0.69 2.3 × 10 −19 1.09 (1.07–1.10) GREB1 3q26.2c rs35446936 A G 0.24 1.0 × 10 −08 1.06 (1.04–1.08) TERC 4q12c rs62323682 T C 0.94 4.9 × 10 −18 1.15 (1.12–1.19) LNX1, PDGFRA 4q13.3c rs12640488 A G 0.52 4.0 × 10 −14 1.06 (1.05–1.08) SULT1B1 4q22.3 rs4699299 T C 0.69 4.7 × 10 −08 1.05 (1.03–1.07) PDLIM5 5p15.33c rs72709458 T C 0.23 4.7 × 10 −21 1.10 (1.08–1.13) TERT 5q35.2c rs2456181 C G 0.49 1.1 × 10 −11 1.06 (1.04–1.08) ZNF346, UIMC1 6p21.31 rs116251328 A T 0.02 3.0 × 10 −08 1.15 (1.09–1.21) GRM4, HMGA1 6q25.2b,c rs58415480 C G 0.84 1.9 × 10 −54 1.19 (1.17–1.22) SYNE1, ESR1 7q31.2 rs2270206 A C 0.16 4.6 × 10 −08 1.06 (1.04–1.09) WNT2 9p24.3c rs10976689 A G 0.60 2.4 × 10 −13 1.06 (1.05–1.08) ANKRD15 10q24.3c rs9419958 T C 0.13 1.1 × 10 −16 1.10 (1.08–1.13) OBFC1, SLK 10p11.22 rs10508765 A G 0.80 1.5 × 10 −10 1.07 (1.05–1.09) ZEB1, ARHGAP12 11p15.5c rs547025 T C 0.92 1.5 × 10 −14 1.13 (1.09–1.16) RIC8A, BET1L 11p14.1b rs11031006 A G 0.14 5.7 × 10 −15 1.10 (1.07–1.12) FSHB 11p13c rs61889186 C G 0.86 1.4 × 10 −25 1.12 (1.10–1.15) WT1 11p13c rs2785202 C G 0.55 6.9 × 10 −14 1.06 (1.05–1.08) PDHX, CD44 11q22.3c rs149934734 T C 0.03 1.1 × 10 −27 1.33 (1.26–1.40) C11orf65, KDELC2 12q13.11c rs2131371 A C 0.28 1.6 × 10 −18 1.08 (1.06–1.10) SLC38A2 12q15 rs11178393 T C 0.89 3.3 × 10 −08 1.08 (1.05–1.10) PTPRR 12q24.31 rs28583837 A G 0.22 2.3 × 10 −08 1.06 (1.04–1.08) PITPNM2 13q14.11c rs117245733 A G 0.02 5.7 × 10 −14 1.31 (1.21–1.39) FOXO1 17p13.1c rs78378222 T G 0.99 7.1 × 10 −31 1.54 (1.43–1.66) SHBG, TP53 20p12.3c rs16991615 A G 0.07 8.8 × 10 −10 1.11 (1.07–1.14) MCM8, TRMT6 22q13.1c rs4821939 A T 0.20 7.8 × 10 −16 1.08 (1.06–1.10) TNRC6B Xp26.2c rs12392108 A T 0.31 5.9 × 10 −46 1.13 (1.11–1.15) RAP2C Xq13.1c rs4360450 A G 0.37 2.1 × 10 −18 1.08 (1.06–1.10) MED12 SNP single-nucleotide polymorphism,RA risk allele, OA other allele, RAFEUR average risk allele frequency in European samples,OR odds ratio a≤300 kb distant from association signal bLoci previously associated with endometriosis cLoci previously associated with UL Corrections & amendments nature communications (2022) 13:5543 | 2

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