Netta Mäkinen — Endo Lab

erratum 2022

Author Correction: Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Nature communications ·doi:10.1038/s41467-022-33222-y

review 2019

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Nature communications ·doi:10.1038/s41467-019-12536-4

Abstract Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 …

article 2018

Abstract LB-375: The landscape of somatic mutations in uterine adenomyomas

·doi:10.1158/1538-7445.am2018-lb-375

Abstract Uterine adenomyosis is a relatively common disorder characterized by the abnormal presence of endometrial glands and stroma in the myometrium. The estimated prevalence of adenomyosis varies between 20-30% in hysterectomy specimens.…

preprint 2018

Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

·doi:10.1101/324905

Uterine leiomyomata (UL), also known as uterine fibroids, are the most common neoplasms of the reproductive tract and the primary cause for hysterectomy, leading to considerable impact on women’s lives as well as high economic burden 1,2 . …

2014

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

Cell reports ·doi:10.1016/j.celrep.2014.03.047

Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis fo…