Hugh S. Taylor

Endometriosis is a common gynecologic disorder characterized by ectopic attachment and growth of endometrial tissues. Resveratrol is a natural polyphenol with antiproliferative and anti-inflammatory properties. Our objective was to study th…

PURPOSE OF REVIEW: To review the latest developments in reproductive tract stem cell biology. RECENT FINDINGS: In 2004, two studies indicated that ovaries contain stem cells which form oocytes in adults and that can be cultured in vitro in…

OBJECTIVE: To evaluate the effect of uterine leiomyomas on the endometrium using molecular markers of endometrial receptivity: HOXA10, HOXA11, LIF, and BTEB1. DESIGN: Case-control study. SETTING: University medical center. PATIENT(S): Th…

Endometriosis is a major cause of chronic pain, infertility, medical and surgical interventions, and health care expenditures. Tissue factor (TF), the primary initiator of coagulation and a modulator of angiogenesis, is not normally express…

Menstruation is a result of the profound tissue remodeling that occurs each month in reproductive-aged women. After withdrawal of steroid hormone support, the functionalis layer of the endometrium undergoes extensive changes, resulting in c…

PURPOSE: endometriosis and its associated infertility have been the object of continuous research for over a century. To understand the molecular mechanisms underlying the disease, it has become necessary to determine the aspects of its eti…

OBJECTIVE: Treat an abdominal wall endometrioma in a post-menopausal patient. DESIGN: Case report. SETTING: Academic medical center. PATIENT(S): A post-menopausal women with a large recurrent abdominal wall endometrioma. INTERVENTION(S)…

OBJECTIVE: To characterize human endometrial HOXA10 expression in patients using a copper intrauterine device (IUD). DESIGN: Case-control study. SETTING: Academic medical center. PATIENT(S): Women using copper IUDs. INTERVENTION(S): Imm…

OBJECTIVE: To evaluate proliferative phase endometrial development in a heterogeneous infertility population. DESIGN: Retrospective study. SETTING: University-based infertility practice. PATIENT(S): Two hundred forty-six treatment cycles…

Dysfunctional stem cells may cause endometriosis posits a new theory. Two experts discuss not only this intriguing theory, but also the latest treatment options, such as aromatase inhibitors, progesterone antagonists, and the levonorgestrel…

Diethylstilbestrol (DES) is a nonsteroidal estrogen that induces developmental anomalies of the female reproductive tract. The homeobox gene HOXA10 controls uterine organogenesis, and its expression is altered after in utero DES exposure. W…

Inflammatory disorders account for a significant percentage of gynecologic disease, particularly in reproductive age women. Inflammation is a basic method by which we respond to infection, irritation, or injury. Inflammation is now recogniz…

Several recent findings in stem cell biology have resulted in new opportunities for the treatment of reproductive disease. Endometrial regeneration can be driven by bone marrow derived stem cells. This finding has potential implications for…

Implantation, a critical step for establishing pregnancy, requires molecular and cellular events resulting in uterine growth and differentiation, blastocyst adhesion, invasion, and placental formation. Successful implantation requires a rec…

Bleeding or inflammation in early pregnancy may result in pregnancy loss or defective implantation. Their effect on HOX gene expression in first trimester decidua is unknown. Bleeding results in thrombin generation, although infection or in…

Calpains have been implicated in the regulation of apoptosis. Here, we identified Calpain5 as a target of HOXA10 transcriptional regulation in endometrial cells as well as its aberrant regulation in endometriosis. Histologically confirmed b…

Tissue factor (TF), is a cellular receptor that binds the ligand factor VII/VIIa to initiate the blood coagulation cascade. In addition to its role as the initiator of the hemostatic cascade, TF is known to be involved in angiogenesis via a…

The eutopic endometrium in women with endometriosis demonstrates diminished endometrial receptivity and altered gene expression. It is unknown if the endometrium being defective gives rise to a predisposition toward endometriosis and infert…

OBJECTIVE: HOXA10 is an essential regulator of endometrial receptivity. To determine the effect of GnRH antagonists on endometrial receptivity, we assessed endometrial HOXA10 expression in GnRH antagonist, GnRH agonist, and natural cycles. …

Endometriosis is a common gynecological disorder that is defined by the presence of endometrial tissue outside the uterine cavity. This disease often results in extensive morbidity, including chronic pelvic pain and infertility. The pathoge…

Endometriosis is one of the most common causes of chronic pelvic pain and infertility. However, the causative factors associated with reduced fecundity have not been clearly elucidated. Due to the limitations associated with controlled stud…

Endometriosis is a poorly understood gynaecologic disorder that is associated with infertility. In this study, we examined the expression of HOXA10 in the eutopic endometrium of baboons with induced endometriosis. A decrease in HOXA10 mRNA …