Hugh S. Taylor
ORCID: 0000-0003-1720-8310
· 313 papers in corpus
lab-animal
2007
Bone marrow-derived cells (BMDCs) can differentiate into nonhematopoietic cells, suggesting that BMDCs may contribute to the maintenance of multiple tissues. Donor-derived bone marrow cells have been identified in human uterine endometrium.…
review
2007
Implantation is a complex event requiring synchronization between a developing embryo and receptive endometrium. This process is governed by molecular mechanism mediated by homeobox (Hox) genes, which encode transcription factors. These fac…
2006
The human endometrium is one of the most dynamic structures in the human body. The remarkable tissue remodeling that occurs in the endometrium is unparallelled in any other organ. Under the influence of the ovarian steroids hormones – estro…
nonrandomized-trial
2006
OBJECTIVE: To evaluate HOXA10 expression in endometriosis. DESIGN: Laboratory study using human tissue. SETTING: Academic research center. PATIENT(S): Eutopic endometrial tissue was collected from 20 fertile women without endometriosis. …
nonrandomized-trial
2006
OBJECTIVE: To determine whether women with hydrosalpinx would have diminished endometrial HOXA10 expression and whether salpingectomy would reverse HOXA10 suppression. The homeobox gene HOXA10 is a transcription factor that is necessary for…
2005
other
2004
EMX2 is a transcription factor necessary for reproductive tract development. Sex steroids regulate endometrial HOXA10 expression, which in turn negatively regulates EMX2. In this study, we characterize menstrual cycle-dependent expression o…
review
2004
Approximately 60% of women with endometriosis are subfertile, that is, their cumulative pregnancy rates are lower than those of controls.1 Although not yet completely understood, it appears that the detrimental effects of endometriosis on f…
nonrandomized-trial
2003
OBJECTIVE: To determine the effects of controlled ovarian hyperstimulation and resultant high levels of E(2) on endometrial HOXA10 expression (a marker of endometrial receptivity). DESIGN: Prospective study. SETTING: University academic m…
observational
1999
HOXA10 and HOXA11 are homeobox genes that function as transcription factors essential to embryonic development. We have recently described a role for each of these two genes in regulating endometrial development in the adult during the cour…
1998
lab-animal
1998
HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium
Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit uterine factor infertility. We have recently d…
other
1998
We have previously shown that interleukin-8 (IL-8), a cytokine with neutrophil chemotactic/activating and T cell chemotactic activity, is produced by human endometrial stromal and glandular cells in culture. The present study investigated t…