HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.

Hugh S. Taylor, Arici A, Olive D, Igarashi P
The Journal of clinical investigation · 1998 · doi:10.1172/jci1057 · PMID:9525980 · PMC508715
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This study demonstrates that HOXA10 expression in the human endometrium increases during the midsecretory phase and is stimulated by estrogen or progesterone, suggesting its role in implantation.

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This study investigated the regulation of HOXA10, a transcriptional regulator essential for embryonic development and uterine function, within the human endometrium during the menstrual cycle. Using Northern blot analysis and in situ hybridization on tissue samples, researchers observed that HOXA10 expression rises significantly during the midsecretory phase when progesterone levels peak, coinciding with the window of implantation. In vitro experiments confirmed that both estrogen and progesterone stimulate HOXA10 production in cultured endometrial cells, identifying sex steroids as direct regulators of this gene. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit uterine factor infertility. We have recently demonstrated that HOXA10 is expressed in the adult human uterus. To examine expression of HOXA10 during the menstrual cycle, Northern blot analysis and in situ hybridization were performed. Expression of HOXA10 dramatically increased during the midsecretory phase of the menstrual cycle, corresponding to the time of implantation and increase in circulating progesterone. Expression of HOXA10 in cultured endometrial cells was stimulated by estrogen or progesterone. Stimulation of HOXA10 by progesterone was concentration-dependent within the physiologic range, and the effect of estrogen was inhibited by cycloheximide. These results identify sex steroids as novel regulators of HOX gene expression. HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human.
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Advertisement Research Article Free access | 10.1172/JCI1057 Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [email protected] Find articles by Taylor, H. in: PubMed | Google Scholar Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [email protected] Find articles by Arici, A. in: PubMed | Google Scholar Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [email protected] Find articles by Olive, D. in: PubMed | Google Scholar Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [email protected] Find articles by Igarashi, P. in: PubMed | Google Scholar Published April 1, 1998 - More info Published in Volume 101, Issue 7 on April 1, 1998 J Clin Invest. 1998;101(7):1379–1384. https://doi.org/10.1172/JCI1057. © 1998 The American Society for Clinical Investigation J Clin Invest. 1998;101(7):1379–1384. https://doi.org/10.1172/JCI1057. © 1998 The American Society for Clinical Investigation Published April 1, 1998 - Version history - Abstract Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit uterine factor infertility. We have recently demonstrated that HOXA10 is expressed in the adult human uterus. To examine expression of HOXA10 during the menstrual cycle, Northern blot analysis and in situ hybridization were performed. Expression of HOXA10 dramatically increased during the midsecretory phase of the menstrual cycle, corresponding to the time of implantation and increase in circulating progesterone. Expression of HOXA10 in cultured endometrial cells was stimulated by estrogen or progesterone. Stimulation of HOXA10 by progesterone was concentration-dependent within the physiologic range, and the effect of estrogen was inhibited by cycloheximide. These results identify sex steroids as novel regulators of HOX gene expression. HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human. - Version history - Version 1 (April 1, 1998): No description Advertisement Advertisement Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)

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