Felice Petraglia

Adenomyosis is an important clinical condition with uncertain prevalence, and clinical focus on adenomyosis in patients undergoing assisted reproductive technology (ART) has increased during recent years. Recognizing the limited clinical kn…

STUDY QUESTION: How important was the change in lumbar spine (L1-L4), femoral neck, and total hip bone mineral density (BMD) from post-treatment baseline values to 24 months after the end of treatment in PRIMROSE 1 and PRIMROSE 2 study part…

Recent advances in understanding endometriosis and adenomyosis pathogenesis have re- vealed crucial molecular mechanisms underlying these debilitating gynecological conditions. This thesis demonstrates the pivotal role of sphingosine-1-phos…

This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and the negative impact on women's quality of life. Furthermore, advancement in our understanding of this…

RESEARCH QUESTION: What is the prevalence of adenomyosis at ultrasonography among adolescents and young women reporting dysmenorrhoea and/or heavy menstrual bleeding (HMB)? DESIGN: This observational cohort study involved adolescents and y…

Endometriosis is a complex disease and still many areas of uncertainty exist on the clinical management, from the diagnosis to the treatment. The modern diagnostic workup should include the family history (including genetic and epigenetic f…

Adenomyosis is a common benign uterine disorders and patients may present dysmenorrhea, dyspareunia, abnormal uterine bleeding (AUB) and infertility. The treatment is very complex, including medical, surgical or radiological approaches. Hor…

• Women with newly diagnosed endometriosis reported an unbalanced dietary pattern. • An unfavorable balance between pro-inflammatory and anti-inflammatory food was found in women with endometriosis. • Patient with endometriosis reported hig…

• Endometriosis is fueled by local estradiol accumulation that might be due to deficient HSD17B2 activity. • The microRNAs miR-124-3p and miR-26b-5p target the HSD17B2 gene. • This study measured miR-124-3p and miR-26b-5p in endometriotic l…

Endometriosis is a complex and chronic gynaecological disorder that affects millions of women worldwide, leading to significant morbidity and impacting reproductive health. This condition affects up to 10% of women of reproductive age and i…

OBJECTIVES: To explore the imaging features and the molecular characterization of adenomyosis after menopause. STUDY DESIGN: An observational cross-sectional study was performed in a group of postmenopausal patients undergoing a transvagin…

Iron deficiency (ID) and iron deficiency anemia (IDA) are very common in women during their reproductive life, but often these conditions remain unrecognized and left untreated, particularly in low/ middle income countries (LMICs). Heavy me…

STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone ac…

BACKGROUND: Dienogest (DNG) improves endometriosis-associated pain (EAP) and patients' quality of life; however, the modern cornerstone of the management of endometriosis is the long-term adherence of the patient to medical treatment. OBJE…

Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, …

Recognizing the limited information, vague diagnostic criterion, and difficult clinical challenges posed by adenomyosis, the Society of Endometriosis and Uterine Disorders organized an expert symposium to present the current understanding o…

Endometriosis is a chronic gynecological syndrome characterized by endometrial cell invasion of the extra-uterine milieu, pelvic pain and infertility. Treatment relies on either symptomatic drugs or hormonal therapies, even though the mecha…

Uterine fibroids (UFs) are the most common female benign pelvic tumors, affecting >60% of patients aged 30-44 years. Uterine fibroids are asymptomatic in a large percentage of cases and may be identified incidentally using a transvaginal ul…

Endometriosis, a chronic gynecological disease, affects millions of women worldwide, significantly impacting their quality of life. A reported delay, ranging from 4 to 12 years, exists between the onset of symptoms and the formal diagnosis.…

BACKGROUND: Sexual health is a major concern in women with endometriosis, however only a few controlled studies have examined this with validated instruments. The effect of hormonal treatments on sexual function in endometriosis is also an …

RESEARCH QUESTION: Women with endometriosis are frequently affected by headache. How many of these have a clear diagnosis of migraine? Are the different forms of migraine related to the phenotypes and/or characteristics of endometriosis? D…