González-Ramos R

No ORCID on file · 13 papers in corpus · active 2007-2016

Study types

  • article 9
  • review 4

Condition tags

  • endometriosis 13
  • infertility 2
article 2016
Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1: implications for endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.04.002

ObjectiveTo evaluate divalent metal transporter-1 (DMT1) expression in healthy women's and endometriosis patients' endometrium and to analyze DMT1 and ferritin light chain (Fn-L) expression modulation by iron overload and IL-1β in endometri…

article 2015
Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation
Biological research ·doi:10.1186/s40659-015-0047-2

BACKGROUND: Endometriosis, pro-inflammatory and invasive benign disease estrogen dependent, abnormally express in endometria the enzyme P450Arom, positively regulated by steroid factor-1 (SF-1). Our objective was to study the nuclear protei…

article 2014
Iron overload–modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis
Fertility and sterility ·doi:10.1016/j.fertnstert.2014.10.046

ObjectiveTo evaluate the effect of iron overload on nuclear factor kappa-B (NF-κB) activation in human endometrial stromal cells (ESCs).DesignExperimental study.SettingUniversity hospital research laboratory.Patient(s)Ten healthy women.Inte…

review 2012
Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.06.021

OBJECTIVE: To update, analyze, and summarize the literature concerning nuclear factor-kappaB (NF-κB) participation in endometriosis pathophysiology. DESIGN: Review. RESULT(S): Nuclear factor-kappaB is physiologically activated in the huma…

review 2011
Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis.
Histology and histopathology ·doi:10.14670/hh-26.1083

Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometri…

article 2011
Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patients
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.12.006

ObjectiveTo evaluate nuclear factor kappaB (NF-κB) activation and NF-κB-p65 subunit activation, immunolocalization, and expression in the endometrium of healthy women and endometriosis patients throughout the menstrual cycle.DesignProspecti…

review 2010
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.01.013

ObjectiveTo evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis.DesignA literature search was conducted in PubMed to identify all relevant citations.Result(s)Our findings highlight the important role of NF-κB…

article 2008
Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.02.103

ObjectiveTo further investigate peritoneal iron disruption in endometriosis by studying iron storage in peritoneal macrophages of patients with endometriosis compared with controls.DesignCross-sectional study.SettingAcademic gynecology rese…

review 2008
Potential involvement of iron in the pathogenesis of peritoneal endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gan033

The aim of this study is to review the current literature associating endometriosis with iron and to discuss the potential causes and consequences of iron overload in the pelvic cavity. Indeed, iron is essential for all living organisms. Ho…

article 2008
Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta)
Gynecologic and obstetric investigation ·doi:10.1159/000127447

BACKGROUND/AIMS: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. METHODS: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometrio…

article 2007
Agents Blocking the Nuclear Factor-κB Pathway Are Effective Inhibitors of Endometriosis in an in vivo Experimental Model
Gynecologic and obstetric investigation ·doi:10.1159/000111148

BACKGROUND: In vitro studies suggest that the transcription factor nuclear factor-kappa B (NF-kappaB) is implicated in the transduction of proinflammatory signals in endometriosis. The aim of this study was to investigate the involvement of…

article 2007
Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.06.015

Endometriosis is characterized by pelvic inflammation that shows an increased number of activated peritoneal macrophages and their secreted products such as cytokines, growth factors, and angiogenic factors. Our results show that activation…

article 2007
Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gam033

Red (active), black and white endometriotic lesions are characteristic of peritoneal endometriosis. The transcription factor nuclear factor-kappa B (NF-kappaB) activates proinflammatory, proliferative and antiapoptotic genes in many cell ty…