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OBJECTIVE: To study the role of the mesothelial cells in early endometriosis lesion formation by assessing in vitro cell-to-cell communication and invasion of endometrial cells across a mesothelial cell monolayer, with both cell types deriv…
Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells retrogradely enter the peritoneum during …
Abstract Endometriosis is an invasive disease, and a leading cause of pain, infertility and disability among women, with an incidence 10 fold that of cancer. A more complete understanding of disease pathogenesis is essential for the develop…
ContextThe relationship between reproductive and cardiometabolic aging is unclear. It is unknown if the relationship differs across different clinical populations.ObjectiveTo determine whether markers of ovarian reserve are associated with …
Study questionAre intrauterine insemination (IUI) performance characteristics and post-processing total motile sperm count (TMC) related to live birth rate in couples with unexplained infertility?Summary answerPatient discomfort with IUI an…
PurposeTo assess the effect of assisted hatching (AH) on live birth rate (LBR) in first cycle, fresh in vitro fertilization (IVF) in good and poor prognosis patients.MethodsRetrospective cohort using cycles reported to the Society for Assis…
ObjectiveTo study whether there is a difference in the prevalence of non-cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI).DesignA secondary analy…
ObjectiveTo assess the effect of assisted hatching (AH) on live-birth rates in a retrospective cohort of patients undergoing first-cycle, autologous frozen embryo transfer (FET).DesignLongitudinal cohort using cycles reported to the Society…
Study questionDoes fertility-related quality of life (FertiQOL) differ by infertility diagnosis between women with polycystic ovary syndrome (PCOS) and their partners, compared with couples with unexplained infertility (UI)?Summary answerWo…
ObjectiveTo evaluate assisted reproduction technology (ART) usage and outcomes in minority women seeking care at enhanced access, military ART programs.DesignRetrospective cohort.SettingFederal ART programs.Patient(s)Two thousand fifty wome…
ObjectiveTo determine the efficacy of anti-tumor necrosis factor therapy (etanercept) for treating endometriosis in baboons.DesignA randomized, placebo-controlled, blinded study using the baboon endometriosis model.SettingSouthwest National…