Torrance HL

BackgroundIn IVF/ICSI treatment, the process of embryo implantation is the success rate-limiting step. Endometrial scratching has been suggested to improve this process, but it is unclear if this procedure increases the chance of implantati…

Study questionIs a single endometrial scratch prior to the second fresh IVF/ICSI treatment cost-effective compared to no scratch, when evaluated over a 12-month follow-up period?Summary answerThe incremental cost-effectiveness ratio (ICER) …

Study questionDoes endometrial scratching in women with one failed IVF/ICSI treatment affect the chance of a live birth of the subsequent fresh IVF/ICSI cycle?Summary answerIn this study, 4.6% more live births were observed in the scratch g…

Study questionCan a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed?Summary answerA minimum data set, known as a core outcome set, has been developed for randomized…

Study questionCan consensus definitions for the core outcome set for infertility be identified in order to recommend a standardized approach to reporting?Summary answerConsensus definitions for individual core outcomes, contextual statement…

STUDY QUESTION: Can the priorities for future research in infertility be identified? SUMMARY ANSWER: The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction…

Study questionDo cumulative live birth rates (CLBRs) over multiple IVF/ICSI cycles confirm the low prognosis in women stratified according to the POSEIDON criteria?Summary answerThe CLBR of low-prognosis women is ~56% over 18 months of IVF/…

Study questionWhat is the effect of endometrial scratching in patients with or without prior failed ART cycles on live birth (LBR) and clinical pregnancy rates (CPR)?Summary answerIt remains unclear if endometrial scratching improves the ch…

Study questionsWe aim to produce, disseminate and implement a core outcome set for future infertility research.What is known alreadyRandomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes,…

BackgroundIn the Netherlands, couples with unexplained infertility and a good prognosis to conceive spontaneously (i.e. Hunault > 30%) are advised to perform timed intercourse for at least another 6 months. If couples fail to conceive withi…

BackgroundSuccess rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positi…