Yu JJ

No ORCID on file · 8 papers in corpus · active 2015-2018

Study types

  • article 4
  • other 1
  • rct 1

Condition tags

  • endometriosis 5
  • adenomyosis 2
article 2018
Indoleamine 2,3-dioxygenase suppresses the cytotoxicity of NK cells in response to ectopic endometrial stromal cells in endometriosis
Reproduction (Cambridge, England) ·doi:10.1530/rep-18-0112

It has been reported that the impaired cytotoxicity of natural killer (NK) cells and abnormal cytokines that are changed by the interaction between ectopic endometrial cells and immune cells is indispensable for the initiation and developme…

other 2018
The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity
Cell death & disease ·doi:10.1038/s41419-018-0581-2

Endometriosis (EMS) is an estrogen-dependent gynecological disease with a low autophagy level of ectopic endometrial stromal cells (eESCs). Impaired NK cell cytotoxic activity is involved in the clearance obstruction of the ectopic endometr…

2017
Protopanaxadiol and metformin synergistically inhibit estrogen-mediated proliferation and anti-autophagy effects in endometrial cancer cells.
American journal of translational research

Metformin is commonly used for treating type II diabetes and has recently been reported to possess anti-proliferative properties that can be exploited for the prevention and treatment of a variety of cancers. Ginsenosides are the main effec…

article 2016
IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis
Reproduction (Cambridge, England) ·doi:10.1530/rep-16-0089

Endometriosis (EMS) is associated with an abnormal immune response to endometrial cells, which can facilitate the implantation and proliferation of ectopic endometrial tissues. It has been reported that human endometrial stromal cells (ESCs…

article 2016
Macrophages promote the growth and invasion of endometrial stromal cells by downregulating IL-24 in endometriosis
Reproduction (Cambridge, England) ·doi:10.1530/rep-16-0278

Macrophages play an important role in the origin and development of endometriosis. Estrogen promoted the growth of decidual stromal cells (DSCs) by downregulating the level of interleukin (IL)-24. The aim of this study was to clarify the ro…

rct 2016
[Research of gestrinone-related abnormal uterine bleeding and the intervention in the treatment: a multi-center, randomized, controlled clinical trial]
Zhonghua fu chan ke za zhi ·doi:10.3760/cma.j.issn.0529-567X.2016.02.004

OBJECTIVE: To investigate the incidence, influencing factors and intervention of gestrinone-related abnormal uterine bleeding at different dosage of gestrinone in the clinical treatment. METHODS: This was a multicenter, randomized, control…

article 2015
Blocking IL-22, a potential treatment strategy for adenomyosis by inhibiting crosstalk between vascular endothelial and endometrial stromal cells.
American journal of translational research

Our previous work has demonstrated that interleukin-22 (IL-22) enhances the invasiveness of endometrial stromal cells (ESCs) of adenomyosis in an autocrine manner. In the present study, we further investigated whether IL-22 mediated crossta…

2015
Chlamydia muridarum infection associated host MicroRNAs in the murine genital tract and contribution to generation of host immune response.
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12281

ProblemChlamydia trachomatis (CT) is the leading sexually transmitted bacterial infection in humans and is associated with reproductive tract damage. However, little is known about the involvement and regulation of microRNAs (miRs) in genit…