Inka Wiegratz

BackgroundThe present study compared the efficacy and safety of a combined oral contraceptive containing 30 mcg ethinylestradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year of treatment.Study designIn …

The effects of extended regimens of combined oral contraceptives (COCs) on carbohydrate metabolism are largely unknown. The present study compared the effects of a COC containing 30 microg ethinylestradiol and 2 mg dienogest (EE/DNG) in con…

OBJECTIVES: To investigate prescribing preferences and personal experience of female gynaecologists with extended-cycle use of combined oral contraceptives (COCs) in Germany and Austria. METHODS: A questionnaire on prescribing patterns and …

BackgroundThe effects of extended regimens of combined oral contraceptives (COC) on lipid parameters are largely unknown. The present study compared the effects of a COC containing 30 mcg ethinyl estradiol and 2 mg dienogest (EE/DNG) in con…

BackgroundThis study was conducted to investigate the effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on thyroid hormones and androgen parameters.Study designThyroid and androgen parameters were measu…

BackgroundThe study was conducted to investigate the effect of a combined oral contraceptive (COC) containing 30 mcg ethinylestradiol and 2 mg dienogest with two different regimens on various hemostasis variables.Study designHemostatic para…

ObjectiveEnlargement of the junctional zone (JZ) on T2-weighted resonance imaging of the uterus has recently been established as the major criterion for adenomyosis in patients with endometriosis. This study was conducted to analyse the ext…

Einleitung: Gewebeproben von peritonealer Endometriose, Adenomyose und von basalem Endometrium zeigten die gleichen zyklischen immunhistochemischen Veränderungen bezüglich der Hormonrezeptoren sowie der P-450 Aromatase*. Da beschrieben wurd…

ObjectiveTo illustrate the influence of pregnancy on primary umbilical endometriosis.DesignCase report.SettingGynecologic endocrinology outpatient department of a university hospital.Patient(s)27-year-old nulliparous woman.Intervention(s)Su…

The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, sperm is transported in the preovulatory phase to maximize fertility, and third, t…

Fragestellung: In letzter Zeit mehren sich die Hinweise, dass eine Adenomyose mit einer Prävalenz von bis zu 85% bei Endometriose vorliegt. Der Ausprägungsgrad der Adenomyose ist von entscheidender Bedeutung für die Fertilität der Patientin…

Hintergrund: Die Erweiterung der Übergangszone ("junctional Zone", JZ) in der Magnetresonanztomographie (MRI) gilt als Hauptkriterium der Adenomyose1. Da die schwere Dysmenorrhoe das Leitsymptom der Endometriose darstellt, aber nie mit eine…

During the use of long-cycle regimens of monophasic oral contraceptives, the total number of bleeding and cycle-dependent complaints is considerably lower than during conventional treatment with oral contraceptives. Despite an initially hig…

ObjectiveTo examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG).DesignProspective observational study.SettingPopulation-based cohort in Germany.Patient(s)Women who wished to becom…

OBJECTIVE: Uterine hyperperistalsis and dysperistalsis are common phenomena in endometriosis and may be responsible for reduced fertility in cases of minimal or mild extent of disease. Since a high prevalence of adenomyosis uteri has been w…

In einer prospektiven, randomisierten, multizentrischen Studie wurden insgesamt 1315 Frauen im Alter zwischen 18 und 40 Jahren mit 30µg Ethinylestradiol + 2mg Dienogest entweder für 13 konventionelle (21 Tabletten) oder 4 Langzyklen (84 Tab…

endometriums with endometriosis, which were labeled with Cy5-dUTP. Fluorescent labeled probes were hybridized on a microarray of 4800 human genes. Results: We could detect many genes expressed differently in eutopic endometrium with or with…

Fragestellung: Retrospektiven Untersuchungen haben gezeigt, dass die Fertilität nach dem Absetzen eines oralen Kontrazeptivums (OC) für die Dauer von bis zu 2 Jahren negativ beeinflusst werden kann. Bei repräsentativen Umfragen nahmen in Dr…

Hintergrund: Gewebe von Endometriose-und Adenomyoseherden imitieren die zyklischen Veränderungen der Hormonrezeptoren des basalen Endometriums. Da der Nachweis erbracht wurde, dass bei Patientinnen mit Endometriose eine höhere Prävalenz an …

This is the first double-blind, controlled, randomized study comparing the effect of different estrogen components in oral contraceptives (OCs) on hemostasis variables. Four groups of 25 women each were treated for six cycles with monophasi…

The conventional regimen of oral contraceptive (OC) use mimics the natural cycles by causing regular withdrawal bleeding, which can be avoided by omission of the hormone-free interval of 7 days. Consequently, long-cycle regimens with contin…

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on thyroid hormone parameters, cortisol, aldosterone, endothelin-1 and angiotensin II was investigated. Four groups …

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on lipid metabolism was investigated. Four groups composed of 25 volunteers each (mean age 26.1 +/- 4.5 years; body …