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BACKGROUND: Chronic pelvic pain affects one in four women. Botulinum toxin, approved for chronic migraine and cervical dystonia pain, is an emerging treatment for other pain conditions. We evaluated intramuscular pelvic floor botulinum toxi…

Some chronic pain conditions and comorbidities suppress the hypothalamic-pituitary-adrenal (HPA) axis and response to dynamic testing. We measured HPA axis responses to corticotropin-releasing hormone (CRH) administration in relation to chr…

BACKGROUND AND OBJECTIVES: Many women with endometriosis continue to have pelvic pain despite optimal surgical and hormonal treatment; some also have palpable pelvic floor muscle spasm. We describe changes in pain, spasm, and disability aft…

OBJECTIVE: To evaluate sensitization, myofascial trigger points, and quality of life in women with chronic pelvic pain with and without endometriosis. METHODS: A cross-sectional prospective study of women aged 18-50 years with pain suggest…

PURPOSE: To describe lifetime differences in clinical characteristics of women with endometriosis between the USA and Puerto Rico. METHODS: A descriptive study using self-administered demographic and clinical questionnaires was undertaken. …

OBJECTIVE: To study whether pain location is related to lesion location in women with chronic pelvic pain and biopsy-proven endometriosis. METHODS: A secondary analysis was performed to compare self-reported pain location with recorded lapa…

OBJECTIVE: To assess the prevalence of patient-reported, physician-diagnosed comorbid conditions in women with endometriosis. DESIGN: Cross-sectional study of self-reported survey data. SETTING: Academic research. PATIENT(S): Four thousa…

ObjectiveTo examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis.DesignProspective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis…

OBJECTIVE: To determine whether first physician seen and symptoms beginning in adolescence have an impact on the diagnostic experience of endometriosis. DESIGN: Cross-sectional study of self-reported survey data. SETTING: Academic researc…

ObjectiveTo develop a model that uses individual and lesion characteristics to help surgeons choose lesions that have a high probability of containing histologically confirmed endometriosis.DesignSecondary analysis of prospectively collecte…

OBJECTIVE: To evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis. METHODS: Women with chronic pelvic pain and no endometriosis treatment for 6 months underwent laparoscopy f…

OBJECTIVE: To correlate histology with endometriosis characteristics. DESIGN: Secondary data analysis. SETTING: Government research hospital. PATIENT(S): One hundred thirty-three women with chronic pelvic pain and endometriosis who under…

ObjectiveTo determine the relationship between disease severity and patient characteristics in endometriosis.DesignCross-sectional study of self-reported survey data.SettingAcademic research setting.Patient(s)One thousand women in the Oxfor…

ObjectiveTo examine the lifetime utilization and perceived benefit of medical treatments and surgical procedures for endometriosis-related symptoms.DesignCross-sectional study of self-reported survey data.SettingAcademic research setting.Pa…

ObjectiveTo evaluate whether persistence of pelvic pain after excision of endometriosis was associated with adenomyosis as defined by a thickened uterine junctional zone (JZ) on magnetic resonance (MR) imaging.DesignProspective clinical tri…

ObjectiveTo evaluate adhesion reformation after laparoscopic excision of endometriosis and adhesiolysis in women with chronic pelvic pain.DesignProspective clinical trial.SettingUniversity hospital.Patient(s)Thirty-eight women with endometr…

OBJECTIVE: To determine whether urine VEGF is elevated in women with endometriosis. DESIGN: Prospective observational study. SETTING: Tertiary care government and private hospitals. PATIENT(S): During laparoscopy for pelvic pain or infer…

BACKGROUND: Women with endometriosis may also have associated disorders related to autoimmune dysregulation or pain. This study examined whether the prevalence of autoimmune, chronic pain and fatigue and atopic disorders is higher in women …

ObjectiveTo correlate the diagnosis of endometriosis in lesions excised at laparoscopy with pathologic diagnosis.DesignProspective study.SettingU.S. government research hospital.Patient(s)Women with chronic pelvic pain thought to be due to …