Wei Zhou — Endo Lab

other 2026

Characterization of elevated levels of endometrial renin-angiotensin system components suggest a role in endometrial repair

Frontiers in endocrinology ·doi:10.3389/fendo.2026.1817846

INTRODUCTION: Each month, the endometrium is shed, regenerated, and transformed in response to changing hormone levels. These processes occur in a tightly regulated manner, and irregularities are linked with reproductive health conditions s…

erratum 2026

Corrigendum to "Integrative single-cell analysis reveals Bu-Shen-Huo-Xue Formula rescues iron-overloaded ovarian function via rewiring IFN-γ/JAK/STAT/CXCL10-driven immune-stromal interactions and BNIP3-mediated mitophagy in endometriosis" [Phytomedicine 2026 May:157:158343]

Phytomedicine : international journal of phytotherapy and phytopharmacology ·doi:10.1016/j.phymed.2026.158445

article 2026

Integrative single-cell analysis reveals Bu-Shen-Huo-Xue Formula rescues iron-overloaded ovarian function via rewiring IFN-γ/JAK/STAT/CXCL10-driven immune-stromal interactions and BNIP3-mediated mitophagy in endometriosis

Phytomedicine : international journal of phytotherapy and phytopharmacology ·doi:10.1016/j.phymed.2026.158343

BACKGROUND: Ovarian endometriosis (OE) is a leading cause of female infertility. Our previous work identified iron overload-driven oxidative stress and mitochondrial dysfunction in granulosa cells as key pathogenic features, yet the mechani…

other 2025

Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women

Research square ·doi:10.21203/rs.3.rs-8116602/v1

We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of the Global Biobank Meta-Analysis Initiative (GBMI). Ou…

article 2025

Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility

Advanced science (Weinheim, Baden-Wurttemberg, Germany) ·doi:10.1002/advs.202417528

Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates t…

other 2025

ROBO3 Drives Endometriosis Progression via Dual Wnt/β-Catenin Activation and M2 Macrophage Polarization

Biological & pharmaceutical bulletin ·doi:10.1248/bpb.b25-00262

Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guid…

other 2024

Expanding the genetic landscape of endometriosis: Integrative -omics analyses uncover key pathways from a multi-ancestry study of over 900,000 women

medRxiv : the preprint server for health sciences ·doi:10.1101/2024.11.26.24316723

We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis consisting of a large portion (31%) of non-European samples across 14 biobanks worldwide as part of the Global Biobank Meta-Analysis Initiative …

dataset 2023

Additional file 2 of A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

·doi:10.6084/m9.figshare.23788451

Additional file 2. Data 1. Inhibition rate of natural compounds on ovarian cancer cells.

dataset 2023

Additional file 3 of A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

·doi:10.6084/m9.figshare.23788454

Additional file 3. Data 2. Primer sequence.

2023

High dosage of gonadotropins is associated with increased risk of preterm birth in singletons born after fresh embryo transfer

·doi:10.21203/rs.3.rs-2669191/v1

Abstract Research Question:Does high gonadotropin dosage affect perinatal outcomes of preterm birth (PTB) and low birth weight (LBW) in singletons born after fresh embryo transfer (ET) cycles? Design: This retrospective cohort study includ…

article 2022

Inhibition of Chemerin/CMKLR1 Axis Mitigates the Endometriosis Progression

·doi:10.2139/ssrn.4049631

article 2022

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression

Frontiers in pharmacology ·doi:10.3389/fphar.2022.985618

Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with limited therapeutics. Chemerin is a sec…

preprint 2021

Clinical Outcomes of Sildenafil Application in Patients of Poor Endometrial Development

·doi:10.21203/rs.3.rs-560961/v1

Abstract Problem: Does sildenafil have an effect on pregnancy outcomes in patients with poor endometrial development?Methods: This study included 472 infertility patients who underwent in vitro fertilization/intracytoplasmatic sperm inject…

article 2020

Dissecting the mechanism of Yuzhi Zhixue granule on ovulatory dysfunctional uterine bleeding by network pharmacology and molecular docking

Chinese medicine ·doi:10.1186/s13020-020-00392-0

BACKGROUND: Yuzhi Zhixue Granule (YZG) is a traditional Chinese patent medicine for treating excessive menstrual flow caused by ovulatory dysfunctional uterine bleeding (ODUB) accompanied by heat syndrome. However, the underlying molecular …

preprint 2020

Dissecting the Mechanism of Yuzhi Zhixue Granule on Ovulatory Dysfunctional Uterine Bleeding by Network Pharmacology and Molecular Docking

·doi:10.21203/rs.3.rs-45961/v1

Abstract Background: Yuzhi Zhixue Granule (YZG)is a traditional Chinese patent medicine for treating excessive menstrual flow caused by ovulatory dysfunctional uterine bleeding (ODUB) accompanied by heat syndrome. However, the underlying mo…

article 2017

Perfluoroalkyl substances and endometriosis-related infertility in Chinese women

Environment international ·doi:10.1016/j.envint.2017.03.003

Endometriosis is one of the main causes for female infertility. Previous studies suggested that perfluoroalkyl substances (PFASs), a group of ubiquitous environmental chemicals with properties of endocrine disruption and reproductive toxici…

2010

Chinese medicinal compound effective component for treating gynecological diseases and preparation method and application thereof