Hui Chen

Endometriosis is one of the most common benign gynecological disorders, characterized by persistent pain and challenges with fertility. Anoikis, a specific form of apoptosis, occurs when cells detach from the extracellular matrix. Recent re…

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profi…

STUDY OBJECTIVE: To investigate whether different timings of GnRH-a downregulation affected assisted reproductive outcomes in infertile women with moderate-to-severe intrauterine adhesions (IUAs) accompanied by adenomyosis. DESIGN: A retro…

Breast cancer patients have high serum reactive oxygen species (ROS) levels, which exert toxicity on the ovary. However, it is still unclear whether tumor-derived ROS play a role in endometrial development and function in breast cancer. Bre…

Background: Subtle distal fallopian tube abnormalities are a group of diseases characterised by small variations in tubal anatomy. The clinical significance of these abnormalities need to be studied. Objectives: The purpose of this multicen…

Biologically active and nanoscale extracellular vesicles (EVs) participate in a variety of cellular physiological and pathological processes in a cell-free manner. Unlike cells, EVs not only do not cause acute immune rejection, but are much…

Objective: Ligustrazine is an amide alkaloid, with the active substance being Chuanxiong. Also known as tetramethylpyrazine (TMP), ligustrazine has various pharmacological effects and has been used to treat a variety of diseases. Many studi…

Approximately 10% (176 million) of women of reproductive age worldwide suffer from endometriosis, which has a high rate of postoperative recurrence. The objective of this study was to investigate the risk factors of severe endometriosis and…

MiR-145 has been shown to suppress cell invasiveness and proliferation in endometriosis, whereas prostate cancer-associated transcript 1 (PCAT1) was reported to act as a sponge of miR-145 with one single-nucleotide polymorphism (SNP), rs710…

OBJECTIVE: To investigate the therapeutic mechanism of bazedoxifene, the third-generation selective ER modulator (SERM), on endometriosis lesions in a rat model. METHODS: Endometriosis was induced by transplanting pieces of endometrium from…

Endometriosis involving intestinal mucosa is relatively uncommon. It poses a diagnostic challenge for clinicians and pathologists. We herein report a case of colonoscopic specimen revealing rectal mucosal endometriosis. A 39-year-old woman …

Premature ovarian failure (POF) appears to be a complex disease entity with several underlying etiopathogenic contributions including the possibility of multiple distinctly different autoimmune mechanisms, in which inflammatory autoimmunity…

Objective To investigate the application value of Colorful Doppler Flow Imaging(CDFI) in differential diagnosis of uterine myoma and adenomyosis.Methods CDFI ultrasonography and blood changes of 866 cases uterine fibroids,uterine adenomyosi…

Objective To evaluate the uterine artery embolization for the treatment of adenomyosis of the clinical effect.Methods January 2008-January 2010 with uterine artery embolization for treatment of 69 cases of patients with adenomyosis,with ute…

Objective To investigate the role of chemokines in peritoneal fluid on pathogenesis of endometriosis(EM).Methods Monocyte chemoattractant protein-1(MCP-1),regulated upon activation normal T cell expressed and secreted(RANTES)contents in per…

BACKGROUND: Visualization and biopsy of suspicious peritoneum can confirm endometriosis. Endoscopic India ink tattooing can lead to peritoneum that visually mimics endometriosis. CASE: A woman with chronic pelvic pain and a history of treat…

Objective To observe the effects of melatonin on cytokines and nature kill cells in endometriosis rat models. Methods Rats were randomly divided into four groups, including normal control group(n=10), model control group(n=10), melatonin gr…