Leyland N

Endometriosis affects 1 in 10 Canadians; however, its financial toxicity remains poorly understood. While universal health care covers physician and hospital services, patients face substantial out-of-pocket costs for medications, complemen…

Lower rates of minimally invasive procedures predispose patients to complications. [1][1] Providers should ensure that all patients receive high-quality care and are aware of all treatment options. Providers should consider access to medica…

OBJECTIVE: To provide a contemporary approach to the understanding of the impact and methods for the diagnosis of endometriosis in Canada. TARGET POPULATION: Individuals, families, communities, health care providers, and health care admini…

Adhesions are a frequent, clinically relevant, and often costly complication of surgery that can develop in any body location regardless of the type of surgical procedure. Adhesions result from surgical trauma inducing inflammatory and coag…

Pain associated with endometriosis is a considerable burden for women, permeating all aspects of their lives, from their ability to perform daily activities to their quality of life. Although there are many options for endometriosis-associa…

Extrapelvic endometriosis, although rare, can present in the musculoskeletal system of reproductive-age women and cause significant pain and morbidity. The pathophysiology of this disease is not well understood. In this study, we described …

ObjectiveTo characterize the health-related quality of life (HRQOL) of Canadian women with a self-reported diagnosis of endometriosis (DxE).MethodsCanadian women aged 18-49 years completed a survey from December 2018 through January 2019 in…

ObjectiveTo evaluate fatigue burden and productivity impairments in Canadian women with a self-reported diagnosis of endometriosis (DxE).MethodsFrom December 2018 to January 2019, Canadian women aged 18-49 years completed an online survey a…

OBJECTIVE: This study sought to estimate the prevalence of diagnosis of endometriosis (DxE) in Canada and to assess the symptomatic and diagnostic experience of Canadian women with DxE. METHOD: A cross-sectional, online survey of women in C…

BackgroundUterine fibroids are common in women and their management is heavily influenced by information gathered through imaging. We aimed to evaluate the type and quality of imaging performed for assessment of uterine fibroids in Canada.M…

Endometriosis can have a profound impact on women's lives, including associated pain, infertility, decreased quality of life, and interference with daily life, relationships, and livelihood. The first step in alleviating these adverse seque…

ObjectifAméliorer la compréhension de l'endométriose et fournir une directive clinique factuelle pour ce qui est du diagnostic et de la prise en charge de l'endométriose.IssuesParmi les issues évaluées, on trouve les effets de la prise en c…

OBJECTIVE: To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain. METHODS: Elaris Endometriosis (EM)-III and -IV were exten…

BACKGROUND: Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Elagolix, an oral, nonpeptide, gonadotropin-releasing hormone (GnRH) antagonist, produced partial to nearly full estrogen suppres…

Numerous biochemical differences have been documented in women with endometriosis compared to controls; however, identification of a clinically useful marker of endometriosis remains elusive. We postulate that the diversity of clinical pres…

ObjectiveTo improve the understanding of endometriosis and to provide evidence-based guidelines for the diagnosis and management of endometriosis.OutcomesOUTCOMES evaluated include the impact of the medical and surgical management of endome…

ObjectiveTo reproduce the earliest phases of endometriosis using a new in vitro model in which cells from a cultured endometrial fragment can proliferate, invade, reconstitute new endometrial-like tissue, and generate blood vessels.DesignEx…