Osamu Wada-Hiraike

No ORCID on file · 44 papers in corpus · active 2012-2026

Study types

  • article 29
  • other 12
  • case-report 1
  • preprint 1
  • review 1

Condition tags

  • endometriosis 31
  • mesh:D004715 26
  • adenomyosis 13
  • endometrioma 10
  • infertility 6
  • dysmenorrhea 4
  • mesh:D004412 2
  • die_deep_infiltrating 1
  • thoracic_endometriosis 1
  • bladder_endometriosis 1
other 2026
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-025-02045-9

The association between adenomyosis and uterine torsion, a rare, serious obstetric condition, remains unclear and has not been systematically investigated. This study aimed to elucidate the incidence, risk factors, and clinical characterist…

other 2026
BMC pregnancy and childbirth ·doi:10.1186/s12884-025-08617-6

BACKGROUND: We aimed to evaluate the risk of perinatal complications in subsequent pregnancies after different types of myomectomy, viz. open, laparoscopic, or hysteroscopic. Moreover, we investigated whether the time interval from myomecto…

preprint 2026
·doi:10.21203/rs.3.rs-8750076/v1
other 2026
Journal of minimally invasive gynecology ·doi:10.1016/j.jmig.2026.03.030
other 2026
Journal of the Endocrine Society ·doi:10.1210/jendso/bvag056

Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological int…

article 2025
BMC pregnancy and childbirth ·doi:10.1186/s12884-025-08454-7

With the increasing incidence of autism spectrum disorder (ASD), various risk factors for ASD have been identified. Among them, maternal immune activation (MIA), which can be triggered by inflammation via elevated proinflammatory cytokines,…

article 2025
Reproductive medicine and biology ·doi:10.1002/rmb2.12654

Purpose: This study evaluated whether embryo cryopreservation before surgery (ECBS) improves clinical outcomes in in vitro fertilization (IVF) patients with endometrioma. Methods: This retrospective study included patients aged 28-42 years …

article 2025
BMC women's health ·doi:10.1186/s12905-025-03817-w

Adenomyosis often causes dysmenorrhea in women of reproductive age. Progestins such as levonorgestrel intrauterine system (LNG-IUS) are often used for treatment, but some patients experience progesterone resistance, showing poor treatment r…

article 2023
BMC pregnancy and childbirth ·doi:10.1186/s12884-023-05956-0

Abstract Background Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy menstrual bleeding. However, the influence of pregnancy on the progression of adenomyo…

article 2022
F&S science ·doi:10.1016/j.xfss.2022.04.004

Objective To evaluate the phosphorylation of estrogen receptor α at serine-118 (phospho-ERα S118) in the endometrium, ovarian endometrioma, and deep infiltrating endometriosis (DIE). Design Experimental study. Setting University-affiliated …

article 2022
Scientific reports ·doi:10.1038/s41598-022-22413-8

The purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome studies. Using a 30 G needle, the entire uterine wall of one horn was mechanically punct…

other 2022
Taiwanese journal of obstetrics & gynecology ·doi:10.1016/j.tjog.2022.02.044

OBJECTIVES: This study aimed to evaluate the course of long-term conservative management of bladder endometriosis (BE). MATERIALS AND METHODS: We retrospectively reviewed 17 cases of BE conservatively managed without surgery in our facilit…

article 2022
Endocrine journal ·doi:10.1507/endocrj.ej22-0158

Dienogest (DNG) is widely used to treat dysmenorrhea associated with estrogen-dependent diseases such as endometriosis and adenomyosis. DNG becomes unnecessary after menopause when estrogen secretion declines drastically. However, there are…

article 2022
BMC women's health ·doi:10.1186/s12905-022-01711-3

Abstract Background In women with endometriosis, the association between ovarian function, hormones, and bone mineral density (BMD) is unclear. Therefore, this study aimed to elucidate the association between changes in bone mineral density…

other 2021
Journal of reproductive immunology ·doi:10.1016/j.jri.2021.103371

OBJECTIVES: This study aimed to determine the systemic and local proportions, focal localization, and characteristics of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in endometriosis. STUDY DESIGN: Peripheral blood and pe…

article 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-019-00041-4
other 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00189-4

When the presence of endometriotic lesions are not evident by hematoxylin and eosin staining, CD10 is used to highlight and confirm the presence of endometriotic stroma. However, CD10 is not specific only to the endometrial stroma but is al…

article 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00186-7
article 2020
Journal of reproductive immunology ·doi:10.1016/j.jri.2020.103104
article 2020
Molecular human reproduction ·doi:10.1093/molehr/gaaa077

Non-hormonal therapeutic strategies for endometriosis are needed. The aim of this study was to characterize the effects of prostaglandin (PG)E2 receptor inhibitors to explore their potential as novel therapeutic strategies for endometriosis…

article 2019
Molecular human reproduction ·doi:10.1093/molehr/gaz066

Endometriosis exerts detrimental effects on ovarian physiology and compromises follicular health. Granulosa cells from patients with endometriosis are characterized by increased apoptosis, as well as high oxidative stress. Endoplasmic retic…

article 2019
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.14059

AIM: This study aimed to describe the clinical presentation, diagnostic evaluation, and operative or medical management of inguinal endometriosis. METHODS: In this study, we retrospectively reviewed 20 cases of inguinal endometriosis in our…

article 2019
BMC women's health ·doi:10.1186/s12905-019-0760-z

BACKGROUND: The recurrence rate after unilateral salpingo-oophorectomy (USO) for unilateral endometrioma has not been reported. We evaluated the rate of and risk factors for endometrioma recurrence after USO. METHODS: In this retrospective …

article 2019
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2019-00281

CONTEXT: The ovarian reserve is reduced in patients with endometriosis. We hypothesize that the phosphatidylinositol 3-kinase (PI3K)-phosphatase and tensin homolog deleted on chromosome 10 (PTEN) Akt-Forkhead box O (Foxo3) pathway is involv…

article 2019
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119831782