Ott S

No ORCID on file · 4 papers in corpus · active 2017-2024

Study types

  • preprint 1

Condition tags

  • endometriosis 1
preprint 2024
Single-cell analysis identifies distinct macrophage phenotypes associated with pro-disease and pro-resolving functions in the endometriotic niche
·doi:10.1101/2024.03.07.583861

Abstract Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in non-hormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in …

2020
Impact of Sustained Transforming Growth Factor-β Receptor Inhibition on Chromatin Accessibility and Gene Expression in Cultured Human Endometrial MSC.
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2020.567610

Endometrial mesenchymal stem cells (eMSC) drive the extraordinary regenerative capacity of the human endometrium. Clinical application of eMSC for therapeutic purposes is hampered by spontaneous differentiation and cellular senescence upon …

2018
Analysis of chromatin accessibility in decidualizing human endometrial stromal cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.201701098r

Spontaneous decidualization of the endometrium in response to progesterone signaling is confined to menstruating species, including humans and other higher primates. During this process, endometrial stromal cells (EnSCs) differentiate into …

2017
Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.
Scientific reports ·doi:10.1038/s41598-017-11674-3

Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requir…