Frontiers in cell and developmental biology

Endometriosis (EMs) is a gynecological disorder affecting women of reproductive age. It is characterized by the ectopic implantation and infiltration of endometrial-like tissue and is associated with significant effects on fertility, pelvic…

Research questionEmbryo quality serves as a pivotal determinant in assisted reproductive technology (ART) outcomes, with high-grade embryos correlating with improved pregnancy/live birth rates but poor morphology elevating the risks of impl…

BackgroundThe relationship between preimplantation hematological profiles and clinical pregnancy rates following frozen embryo transfer (FET) has not been thoroughly investigated.MethodsA retrospective study was conducted. Participants were…

BackgroundGermline mutations in genes governing DNA repair, cell cycle regulation, and epigenetic modification are now recognized as common etiological factors for both cancer predisposition and reproductive dysfunction. This reveals a prof…

Primary dysmenorrhea is currently an unresolved public health problem worldwide, which suffers the patients comprehensive symptoms. Currently, more and more studies have been focusing on biomarker exploration for diagnosis and target therap…

The human endometrium undergoes cyclical regeneration during the menstrual cycle, a process thought to be driven primarily by multipotent stem cells located within the basalis layer. Previous studies have proposed that bone marrow-derived c…

BACKGROUND: Endometriosis is a common estrogen-dependent disease marked by ectopic endometrial growth. Although the PI3K/AKT and kisspeptin pathways are known to regulate endometrial homeostasis, their interplay in disease progression remai…

BACKGROUND: Endometriosis (EMs)-associated infertility has been linked to alterations in the follicular microenvironment; however, the role of exosomal long non-coding RNAs (lncRNAs) in granulosa cell dysfunction remains incompletely unders…

Background: fertilization remains challenging. This study aimed to develop and validate a machine learning model for predicting the cumulative live birth rate in women with endometriomas who underwent alcohol sclerotherapy followed by assis…

BackgroundChronic endometritis (CE), characterized by CD138+ plasma cell infiltration, has been proposed to impair reproductive outcomes in assisted reproductive technology (ART). However, current evidence remains inconsistent, and diagnost…

ObjectiveThis study aims to assess the effects of intrauterine infusion of human umbilical cord blood mononuclear cells (HUCBMCs) on reproductive outcomes in patients with thin endometrium undergoing frozen embryo transfer (FET).DesignProsp…

Pyroptosis is a lytic form of regulated cell death driven by inflammasome activation and gasdermin-mediated membrane rupture, characterized by robust inflammatory amplification. High-mobility group box 1 (HMGB1), a multifunctional nuclear p…

Urological malignancies represent a group of highly aggressive tumors with a strong tendency toward therapy resistance. Their pathogenesis is closely associated with metabolic reprogramming and epigenetic regulation. In recent years, lactyl…

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by reproductive and metabolic disturbances, which causes a chronic lack of ovulation that leads to increased incidence of atypical endometrial hyperplasia and …

Cancer is conventionally viewed as a disease of accumulated somatic mutation and epigenetic dysregulation leading to cell de-differentiation and uncontrolled proliferation. With few exceptions, malignant tumors develop from a single damaged…

Persistent organic pollutants (POPs) are a class of chemical substances with environmental persistence, bioaccumulation, and high toxicity, which are widely present in the environment and food chains. Prostate cancer (PCa) is a highly preva…

Epidemiological inconsistencies currently obscure the causal link between polychlorinated biphenyls (PCBs) and breast cancer. This review synthesizes multi-disciplinary evidence to characterize PCBs not as passive exposure correlates but as…

BackgroundThe copper intrauterine device (Cu-IUD) is a widely used long-term contraceptive method. However, whether prior Cu-IUD use, including long-term exposure, affects reproductive and neonatal outcomes after assisted reproductive techn…

Exosomes, as key mediators of intercellular communication, play a central regulatory role in cellular physiological and pathological processes through their dynamic interaction with the cytoskeleton. The cytoskeleton is a dynamic network co…

Endometrial receptivity (ER) is a pivotal determinant of successful embryo implantation, and its dysfunction is a major cause of infertility and recurrent implantation failure. Mesenchymal stem cells (MSCs) have emerged as a promising thera…

Telomeres are major determinants of chromosome integrity, and when poorly regulated, they have been shown to contribute critically to malignant transformation. However, in gynaecological malignancies, telomeres are interpreted inconsistentl…

ObjectiveTo investigate the interaction effects of anti-Müllerian hormone (AMH), antral follicle count (AFC), basal follicle-stimulating hormone (FSH), and endometrial thickness on the outcomes of assisted reproductive technology (ART).Meth…

Female reproductive tissues repeatedly undergo controlled inflammation, immune adaptation, and tissue repair. Interleukin-33 (IL-33) and its receptor suppression of tumorigenicity 2 (ST2) sit at the center of these processes, but their role…

As a major global health threat, tumors present significant clinical challenges due to their heterogeneity, metastatic potential, and therapy resistance. In recent years, non-coding RNAs, particularly microRNAs (miRNAs), have emerged as cru…