Shibahara H

ObjectiveThis crossover study compared the effects of two recombinant follicle-stimulating hormone (rFSH) preparations, follitropin alfa and follitropin delta, on assisted reproductive technology (ART) outcomes.MethodsPatients aged 25-42 ye…

Study questionIs oocyte developmental competence associated with changes in granulosa cell (GC) metabolism?Summary answerGC metabolism is regulated by the LH surge, altered by obesity and reproductive aging, and, in women, specific metaboli…

ObjectivesThe objective of this study was to investigate the safety and utility of hybrid uterine septal resection.Materials and methodsThis retrospective cohort trial included 16 patients who underwent hybrid uterine septal resection at Hy…

AimThis study aimed to clarify the impact of coronavirus disease 2019 on gynecology practice in Japan, in particular, on surgeries for benign gynecological diseases.MethodsAn online questionnaire was distributed to 966 facilities in Japan, …

The detailed mechanism underlying endometriosis development remains unclear; few reports have suggested the involvement of immune and genetic factors. This study aims to investigate the role of NK cells in endometriosis by analyzing the co-…

PurposeOur aim is to make an ideal embryo culture medium close to human oviduct fluid (HOF) components, and to evaluate the quality of this medium with embryo quality and clinical outcomes in assisted reproductive technology (ART) by a pros…

PurposeLaevo (l)-carnitine plays important roles in reducing the cytotoxic effects of free fatty acids by forming acyl-carnitine and promoting beta-oxidation, leading to alleviation of cell damage. Recently, the mitochondrial functions in m…

PurposeThe fertility of women decreases with age because of factors such as an increased incidence of aneuploidies and-possibly-decreased mitochondrial activity in oocytes. However, the relationship between maternal aging and mitochondrial …

AimTo reveal current problems and challenges faced by our gynecologic services department in managing patients with hereditary cancers.MethodsWe collected clinical data of patients with hereditary cancers, identified via genetic testing (or…

Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or …

PurposeThe oxygen consumption rates (OCRs) in mice and cattle have been reported to change during preimplantation embryogenesis. On the other hand, mitochondrial DNA (mtDNA) copy number has been shown to be unchanged in mice and changed in …

PurposeThe aim of this study was to establish a simple tool to predict good-quality embryos in in vitro fertilization (IVF) by using cumulus cells (CCs) or peripheral blood cells (PBCs).MethodsMitochondrial DNA was extracted from CCs and PB…

•Endometrial stromal sarcoma disseminated after morcellation•Complete remission of pelvic recurrence was achieved by oophorectomy.•Laparoscopic confirmation of remission of recurrent disease.

OBJECTIVE: To investigate the localization of the proteins osteopontin (OPN) and L-selectin (SELL). DESIGN: Retrospective nonrandomized immunohistochemical study in a surgically induced rat model of peritoneal endometriosis and in samples …

Although laparoscopic adenomyomectomy may be a possible risk factor for uterine rupture in subsequent pregnancy, few reports have described it. A 35-year-old woman became pregnant 1 month after laparoscopic adenomyomectomy. At the 28th week…

STUDY OBJECTIVE: To investigate the feasibility and clinical usefulness of transvaginal salpingoscopy (TS) during transvaginal hydrolaparoscopy (THL) in infertile women. DESIGN: Retrospective study (Canadian Task Force classification II-3)…

PROBLEM: Although the presence of mast cells in endometriosis lesions has been reported, there have been no reports of their pathological localization in ovarian endometrial cysts. METHODS OF STUDY: The localization of mast cells in ovaria…

It is well known that Chlamydia trachomatis causes acute and chronic pelvic inflammatory disease including salpingitis. We describe a case of successful pregnancy following conservative treatment of massive ascites associated with acute Chl…

Since transvaginal hydrolaparoscopy (THL) was introduced as the first-line procedure in the early stage of the exploration of the tubo-ovarian structures in infertile women, it has been shown that THL is a less traumatic and a more suitable…

Study objectivesTo investigate the pathophysiology of human endometriosis, we examined by morphological and molecular biological methods.MethodsSamples of ovarian endometriosis and normal ovarian tissues were obtained laparoscopically after…

ObjectiveTo evaluate the usefulness and prognostic value of transvaginal hydrolaparoscopy (THL) in infertile women.DesignRetrospective study.SettingJichi Medical School Hospital, Tochigi, Japan.Patient(s)Thirty-six patients who were followe…